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Cholecystokinin both stimulates and inhibits human food intake

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Abstract

THE hypothesis that gastrointestinal hormone(s) released into the blood during normal digestion should inhibit further food intake is attractive. It has been reported1–4 that injection of cholecystokinin (CCK) inhibited eating in rats and rhesus monkeys. We now report that intravenous infusion of CCK in a dose which produces physiological effects ascribed to CCK during normal digestion stimulated, rather than inhibited, eating in man. In contrast, rapid intravenous injection of CCK inhibited human food intake.

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Authors and Affiliations

  1. Medical and Research Services, Veterans Administration Wadsworth Hospital Center and Department of Medicine, UCLA School of Medicine, Los Angeles, California

    RICHARD A. L. STURDEVANT & HEIDI GOETZ

Authors
  1. RICHARD A. L. STURDEVANT
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  2. HEIDI GOETZ
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STURDEVANT, R., GOETZ, H. Cholecystokinin both stimulates and inhibits human food intake. Nature 261, 713–715 (1976). https://doi.org/10.1038/261713a0

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  • DOI: https://doi.org/10.1038/261713a0

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