Abstract
THE therapeutic usefulness of many anti-cancer agents depends on their selective toxicity for cells in the S (DNA synthesising) phase of the cell cycle1. Thus, rapidly proliferating cancer cells are more effectively killed by these agents than are normal cell populations, which have a lower proportion of cells in S. In theory, it should be possible to reduce the toxicity of such agents significantly by further slowing the entry of normal cells into S. We have tested this possibility in vitro by exploiting the ability of cyclic AMP derivatives to inhibit the entry into S phase of 3T3 cells, but not their malignant counterparts, transformed by SV40.
Similar content being viewed by others
References
Valeriate, F., and van Putten, L., Cancer Res., 2619–2630 (1975).
Johnson, G. S., and Pastan, I., J. natn. Cancer Inst., 48, 1377–1387 (1972).
Rozengurt, E., and Pardee, A. B., J. cell. Physiol., 80, 273–279 (1972).
Froehlich, J. E., and Rachmeler, M., J. Cell Biol., 50, 249–257 (1974).
Paul, D., Nature new Biol., 240, 179–181 (1972).
Smets, L. A., Nature new Biol., 239, 123–124 (1972).
Chasim, M., Harris, D. N., Phillips, M. B., and Hess, S. M., Biochem. Pharmac., 21, 2443–2450 (1972).
Stoker, M. G. P., Proc. R. Soc., B 181, 1–17 (1972).
Pardee, A. B., Proc. natn. Acad. Sci. U.S.A., 71, 1286–1290 (1974).
Toniolo, D., and Basilico, C., Cell, 4, 255–262 (1975).
Vogel, A., and Pollack, R., J. cell Physiol., 25, 151–162 (1975).
Burstin, S. J., and Basilico, C., Proc. natn. Acad. Sci. U.S.A., 72, 2540–2544 (1975).
Bourne, H., Coffino, P., Melmon, K., Tomkins, G., and Weinstein, Y., Adv. cyclic Nucleotide Res., 5, 771–786 (1975).
Pardee, A. B., and James, L., Proc. natn. Acad. Sci. U.S.A., 72, 4994–4998 (1975).
O'Neill, F. J. O., Cancer Res., 35, 1311–1315 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROZENGURT, E., Po, C. Selective cytotoxicity for transformed 3T3 cells. Nature 261, 701–702 (1976). https://doi.org/10.1038/261701a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/261701a0
- Springer Nature Limited
This article is cited by
-
Cell surface and cell division
Cell Biophysics (1982)
-
Tranquillizers can block mitogenesis in 3T3 cells and induce differentiation in Friend cells
Nature (1980)