Skip to main content
SpringerLink
Log in

When smoke gets in your genes

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Abstract

Evidence accumulates that transplacental exposure to cigarette smoke causes genetic damage in utero (pages 1144–1151 ).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Perera, F.P. Environment and cancer: Who are susceptible? Science 278, 1068–1073 (1997).

    Article  CAS  Google Scholar 

  2. Finette, B.A., O'Neill, J.P., Vacek, P.M. & Albertini, R.J. Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke. Nature Med. 4, 1144–1151 (1998).

    Article  CAS  Google Scholar 

  3. Hollstein, M., Sidransky, D., Vogelstein, B. & Harris,C.C. p53 mutations in human cancers. Science 253, 49–53 (1991).

    Article  CAS  Google Scholar 

  4. Denissenko, M.F., Pao, A., Tang, M. & Pfeifer, G.P. Preferential formation of benzo[alpha]pyrene adducts at lung cancer mutational hotspots in p53. Science 274, 430 (1996).

    Article  CAS  Google Scholar 

  5. Brennan, J.A. et al. Association between cigarette smoking and mutation of the p53 gene in squamous cell carcinoma of the head and neck. N. Engl. J. Med. 332, 712–717 ( 1995).

    Article  CAS  Google Scholar 

  6. Ohta, M. et al.The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancer. Cell 84, 587– 597 (1996).

    Article  CAS  Google Scholar 

  7. Sozzi, G. et al. Association between cigarette smoking and FHIT gene alterations in lung cancer. Cancer Res. 57, 2121– 2123 (1997).

    CAS  PubMed  Google Scholar 

  8. Nelson, H.H. et al. Chromosome 3p14 alterations in lung cancer: Evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res. 58, 1804–1807 (1998).

    CAS  PubMed  Google Scholar 

  9. Yunis, J.J., Soreng, A.L. & Bowe, A.E. Fragile sites are targets of diverse mutagens and carcinogens. Oncogene 1, 59– 69 (1987).

    CAS  PubMed  Google Scholar 

  10. Mao, L. et al. Clonal genetic alterations in the lungs of current and former smokers. J. Natl. Cancer Inst. 89, 857– 862 (1997).

    Article  CAS  Google Scholar 

  11. Gu, Y. et al. The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the V(D)J recombinase. Proc. Natl. Acad. Sci. USA 89, 10464–10468 (1992).

    Article  CAS  Google Scholar 

  12. Greenblatt, M.S., Bennett, W.P., Hollstein, M. & Harris, C.C. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855–4878 (1994).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy

    Gabriella Sozzi & Marco A. Pierotti

Authors
  1. Gabriella Sozzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marco A. Pierotti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sozzi, G., Pierotti, M. When smoke gets in your genes. Nat Med 4, 1119–1120 (1998). https://doi.org/10.1038/2614

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2614

  • Springer Nature America, Inc.

Search

Navigation