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Muscle activity decreases rate of degradation of α-bungarotoxin bound to extrajunctional acetylcholine receptors

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Abstract

DURING development of skeletal muscle, and after denervation or reinnervation of adult muscle, there are significant changes in the number of extrajunctional acetylcholine (ACh) receptors, measured both by sensitivity to ACh and by binding of α-125I-bungarotoxin (for review, see ref. 1). Muscle activity has been shown to be a major factor in controlling the level of extrajunctional receptors. Direct electrical stimulation of denervated muscle both in vivo and in vitro decreases the sensitivity of the extrajunctional membrane to ACh2–5, whereas chronic postsynaptic blockade of innervated muscle in vivo increases its sensitivity6,7. Muscle activity could alter the level of extrajunctional receptor by changing rates of synthesis or degradation of the receptor.

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Author notes

  1. ZACH W. HALL

    Present address: Department of Physiology, University of California, San Francisco, California, 94122

  2. JEAN M. MARSHALL: On leave from: Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island 02912.

Authors and Affiliations

  1. Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02115

    PATRICK G. HOGAN, JEAN M. MARSHALL & ZACH W. HALL

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  1. PATRICK G. HOGAN
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  2. JEAN M. MARSHALL
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HOGAN, P., MARSHALL, J. & HALL, Z. Muscle activity decreases rate of degradation of α-bungarotoxin bound to extrajunctional acetylcholine receptors. Nature 261, 328–330 (1976). https://doi.org/10.1038/261328a0

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