Abstract
ERYTHROPOIESIS in chick embryos provides a useful experimental system to study specific gene regulation during embryonic differentiation. As they mature, red blood cells become almost totally committed to the synthesis of one set of gene products—haemoglobin peptide chains. Thus, the transcriptional and post-transcriptional processes involved in the expression of the globin genes can be conveniently studied in erythroid cells undergoing maturation.
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Bruns, G. A. P., and Ingram, V. M., Phil. Trans. R. Soc. B 266, 225–305 (1973).
Chan, L.-N. L., and Ingram, V. M., J. Cell. Biol., 56, 861–865 (1973).
Chan, L.-N. L., Wiedmann, M., and Ingram, V. M., Devl. Biol., 40, 174–185 (Butterworths, London, 1974).
Wilt, F. H., J. molec. Biol., 12, 331–341 (1965).
Kafatos, F. C., and Gelinas, R., MTP Int. Rev. Sci. Biochem. Ser., 9, 223–264 (Butterworths, London, 1974).
Hunt, J. A., Biochem. J., 138, 499–510 (1973).
Gurdon, J. B., Woodland, H. R., and Lingrel, J. B., Devl Biol., 39, 125–133 (1974).
Ross, J., Ikawa, Y., and Leder, P., Proc. natn. Acad. Sci. U.S.A., 69, 3620–3623 (1972).
Weintraub, H., Campbell, G., and Holtzer, H., J. Cell. Biol., 50, 652–668 (1971).
Hagopian, H. K., Lippke, J. A., and Ingram, V. M., J. Cell. Biol., 54, 98–106 (1972).
Ingram, V. M., Chan, L.-N. L., Hagopian, H. K., Lippke, J. A., and Wu, L., Devl. Biol., 36, 411–427 (1974).
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CHAN, LN. Transport of globin mRNA from nucleus into cytoplasm in differentiating embryonic red blood cells. Nature 261, 157–159 (1976). https://doi.org/10.1038/261157a0
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DOI: https://doi.org/10.1038/261157a0
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