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Characterisation of Aleutian disease antigens

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Abstract

ALEUTIAN DISEASE (AD), which affects certain Mustelidae, is a persistent viral infection with development of non-neutralising antibody and gammapathy1–3. Some of the antigens developed in the course of AD are detectable by counter-immunoelectrophoresis (CEP) using sera from chronically infected mink. We have obtained evidence of two antigenic forms, Ag-1 and Ag-2, which have been characterised by molecular size, primary protein subunit components and by electron microscopy. Hollow ring-like structures, similar to those described with such viruses as ϕX1744, rat virus, Haden, adeno-associated virus and others5, were found associated with the AD virus (ADV) and seem to be the predominant antigenic component of Ag-1.

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Author notes

  1. A. J. KENYON: Reprint requests to Walker Laboratory SKI, Rye, N.Y. 10580.

Authors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021

    G. W. NOTANI, E. C. HAHN, N. H. SARKAR & A. J. KENYON

Authors
  1. G. W. NOTANI
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  2. E. C. HAHN
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  3. N. H. SARKAR
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  4. A. J. KENYON
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NOTANI, G., HAHN, E., SARKAR, N. et al. Characterisation of Aleutian disease antigens. Nature 261, 56–58 (1976). https://doi.org/10.1038/261056a0

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  • DOI: https://doi.org/10.1038/261056a0

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