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Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster

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Abstract

ONE way to advance current physiological and biochemical understanding of the mechanism of synaptic transmission at the molecular level is to alter synaptic function by means of single gene mutations. Among the various behavioural mutants of Drosophila melanogaster, those which express a mutant phenotype only in certain conditions and otherwise behave normally are of particular interest. If the mutant phenotype appears at the synapse, the mutant might enable a reversible modification of synaptic function by way of experimentally controlling the expression of the mutant phenotype. Such a mutant would provide a useful tool for the study of synaptic function.

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Author notes

  1. SEIJI OZAWA

    Present address: Department of Physiology, Jichi Medical School, Minami-kawachi-Machi, Kawachi-gun, Tochigi-Ken, Japan

Authors and Affiliations

  1. Division of Neurosciences, City of Hope National Medical Center, Duarte, California, 91010

    KAZUO IKEDA

  2. Department of Physiology, School of Medicine, University of California, Los Angeles, California, 90024

    SEIJI OZAWA & SUSUMU HAGIWARA

Authors
  1. KAZUO IKEDA
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  2. SEIJI OZAWA
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  3. SUSUMU HAGIWARA
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IKEDA, K., OZAWA, S. & HAGIWARA, S. Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster. Nature 259, 489–491 (1976). https://doi.org/10.1038/259489a0

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  • DOI: https://doi.org/10.1038/259489a0

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