Skip to main content
SpringerLink
Log in

Cytotoxicity of antibody-coated trypanosomes by normal human lymphoid cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

DESTRUCTION of antibody-coated mammalian target cells by normal human lymphocytes demonstrated by release of 51Cr-chromate is a phenomenon characterised by its rapidity of action and by the very small amounts of antibody required. It seems unlikely that such a mechanism destroys solely mammalian target cells, and possibly it has a role in immunity to parasitic infections. Butterworth et al.1 demonstrated that normal human blood cells destroy schistosomula coated with antibody from infected patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Butterworth, A. E., Sturrock, R. F., Houba, V., and Rees, P. H., Nature, 252, 503 (1974).

    Article  ADS  CAS  Google Scholar 

  2. Baker, J. R., Green, S. M., Chaloner, L. A., and Gaborak, M., Parasitology, 65, 251 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Molteno Institute, University of Cambridge, Cambridge, CB2 1QP, UK

    J. B. MKWANANZI & D. FRANKS

  2. MRC Unit for Biochemical Parasitology, Molteno Institute, University of Cambridge, Cambridge, CB2 1QP, UK

    J. R. BAKER

Authors
  1. J. B. MKWANANZI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. FRANKS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. R. BAKER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MKWANANZI, J., FRANKS, D. & BAKER, J. Cytotoxicity of antibody-coated trypanosomes by normal human lymphoid cells. Nature 259, 403–404 (1976). https://doi.org/10.1038/259403a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/259403a0

  • Springer Nature Limited

This article is cited by

Search

Navigation