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Enzymatic basis for DDE-induced eggshell thinning in a sensitive bird

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Abstract

ALTHOUGH the thinning of eggshells as a result of ingestion of DDE [2,2-bis-(p-chlorophenyl)-1,1-dichloroethylene] is well documented in many sensitive avian species, the underlying mechanism remains unclear (see ref. 1 for review). Risebrough et al.2 have proposed that thinning results from inhibitory action close to the site of shell formation since other physiological processes are apparently not affected in brown pelicans laying eggs with up to 95% thinned shells. Our report of no reduction in blood calcium in white Pekin ducks and ring doves exhibiting DDE-induced eggshell thinning3 supports the proposal that thinning results from a disruption of shell gland (uterus) function rather than a reduced calcium supply to the gland.

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References

  1. Cooke, A. S., Environ. Pollut., 4, 85–152 (1973).

    Article  CAS  Google Scholar 

  2. Risebrough, R. W., Davis, J., and Anderson, D. W., in The Biological Impact of Pesticides in the Environment (edit. by Gillett, J. W.), 40–53 (Oregon State University Press, Corvallis, 1970).

    Google Scholar 

  3. Peakall, D. B., Miller, D. S., and Kinter, W. B., Environ. Pollut. (in the press).

  4. Simkiss, K., and Taylor, T. G., in Physiology and Biochemistry of the Domestic Fowl (edit. by Bell, D. J. and Freeman, B. M.), 3, 1331–1343 (Academic, New York, 1971).

    Google Scholar 

  5. Harrison, H. E., and Harrison, H. C., in Biomembranes (edit. by Manson, L. A.), 4 B, 793–846 (Plenum, London, 1974).

    Google Scholar 

  6. Pritchard, J. B., Peakall, D. B., Risebrough, R. W., and Kinter, W. B., Bull. Mt Desert Isl. Biol. Lab., 12, 77–79 (1972).

    Google Scholar 

  7. Yamada, M., Poultry Sci., 52, 1375–1382 (1973).

    Article  CAS  Google Scholar 

  8. Pike, W. J., and Alvarado, R. H., Comp. Biochem. Physiol., 51 B, 119–125 (1975).

    CAS  Google Scholar 

  9. Corradino, R. A., Wasserman, R. H., Pubols, M. H., and Chang, S. I., Archs. Biochem. Biophys., 125, 378–380 (1968).

    Article  CAS  Google Scholar 

  10. Schwartz, E., Fedn Proc., 33, 1314 (1974).

    Google Scholar 

  11. Peakall, D. B., Lincer, J. L., Risebrough, R. W., Pritchard, J. B., and Kinter, W. B., Comp. gen. Pharmac., 4, 305–313 (1973).

    Article  CAS  Google Scholar 

  12. Peakall, D. B., Miller, D. S., and Kinter, W. B., Nature, 254, 421 (1975).

    Article  ADS  CAS  Google Scholar 

  13. Bonting, S. L., in Membranes and Ion Transport (edit. by Bittar, E. E.), 1, 257–363 (Wiley-Interscience, London, 1970).

    Google Scholar 

  14. Maren, T. H., J. Pharmac. exp. Ther., 130, 26–29 (1960).

    CAS  Google Scholar 

  15. Wasserman, R. H., and Taylor, A. N., Science, 152, 791–793 (1966).

    Article  ADS  CAS  Google Scholar 

  16. Cade, T. J., Lincer, J. L., White, C. M., Roseneau, D. G., and Swartz, L. G., Science, 172, 955–957 (1971).

    Article  ADS  CAS  Google Scholar 

  17. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).

    CAS  Google Scholar 

  18. Hohman, W., and Schraer, H., J. Cell Biol., 30, 317–331 (1966).

    Article  CAS  Google Scholar 

  19. Maren, T. H., Swenson, E. R., Miller, D. S., and Kinter, W. B., Bull. Mt Desert Isl Biol. Lab., 14, 63–68 (1974).

    Google Scholar 

  20. Maren, T. H., Physiol. Rev., 47, 595–781 (1967).

    Article  CAS  Google Scholar 

  21. Peakall, D. B., in Environmental Dynamics of Pesticides (edit. by Haque, R. and Freed, V. H.), 343–360 (Plenum, New York, 1975).

    Book  Google Scholar 

  22. Glick, N. B., in Metabolic Inhibitors (edit. by Hochster, R. M. Kates, M. and Quastel, J. H.), 3, 1–45 (Academic, New York, 1972).

    Book  Google Scholar 

  23. Schatzmann, H. J., and Tshabold, M., Experientia, 27, 59–61 (1971).

    Article  CAS  Google Scholar 

  24. O'Callaghan, M. A., and Duggan, P. F., Biochem. Pharmac., 24, 563–566 (1975).

    Article  CAS  Google Scholar 

  25. Schraer, R., Elder, J. A., and Schraer, H., Fedn Proc., 32, 1938–1943 (1973).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Mount Desert Island Biological Laboratory, Salsbury Cove, Maine, 04672

    DAVID S. MILLER & WILLIAM B. KINTER

  2. Canadian Wildlife Service, Ottawa, Canada, K1A 083

    DAVID B. PEAKALL

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  1. DAVID S. MILLER
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  2. WILLIAM B. KINTER
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  3. DAVID B. PEAKALL
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MILLER, D., KINTER, W. & PEAKALL, D. Enzymatic basis for DDE-induced eggshell thinning in a sensitive bird. Nature 259, 122–124 (1976). https://doi.org/10.1038/259122a0

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  • DOI: https://doi.org/10.1038/259122a0

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