Abstract
CARSWELL et al.1 described a tumour necrosis factor (TNF) in the sera of mice sensitised with BCG and injected with endotoxin. After intravenous injection of this serum into mice bearing a 7-d-old transplant of a tumour originally induced by methylcholanthrene, necrosis of the tumour began within 12–24 h. A similar response was found in mice bearing various other tumours. We have now found that both whole TNF serum and TNF partially purified from mouse serum2 inhibit the growth of a human melanoma cell line.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Carswell, E. A., et al., Proc. natn. Acad. Sci. U.S.A., 72, 3666–3670 (1975).
Green, S., et al., Proc. natn. Acad. Sci. U.S.A. (in the press).
Everson, T. C., Cole, W. H., Ann. Surg., 144, 366–383 (1956).
Nathanson, L., Cancer Chemother. Rep., 56, 659–665 (1972).
Biedler, J. L., Helson, L., and Spengler, B. A., Cancer Res., 33, 2643–2652 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HELSON, L., GREEN, S., CARSWELL, E. et al. Effect of tumour necrosis factor on cultured human melanoma cells. Nature 258, 731–732 (1975). https://doi.org/10.1038/258731a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/258731a0
- Springer Nature Limited
This article is cited by
-
Zn- and Mg- Containing Tricalcium Phosphates-Based Adjuvants for Cancer Immunotherapy
Scientific Reports (2013)
-
Peptide-Mediated Targeting of Cytokines to Tumor Vasculature: The NGR-hTNF Example
BioDrugs (2013)
-
Activated CD4+T cells enhance radiation effect through the cooperation of interferon-γ and TNF-α
BMC Cancer (2010)
-
Role of TNFα in pulmonary pathophysiology
Respiratory Research (2006)
-
The oncogene PDGF-B provides a key switch from cell death to survival induced by TNF
Oncogene (2005)