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Reduced deformability of erythrocyte membranes from patients with Duchenne muscular dystrophy

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Abstract

THE fundamental defect in Duchenne muscular dystrophy is obscure. Early investigators attributed the disorder to a primary defect of the skeletal muscle itself,1 but alternative suggestions have implicated the motor neurone2,3 or the vascular supply4. Recent attention has been directed to the plasma membrane of muscle as well as of other tissues. Several authors have postulated a generalised membrane defect as the fundamental problem in this disorder5–7.

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References

  1. Walton, J. N., Br. Med. J., 1, 1271 (1964).

    Article  CAS  Google Scholar 

  2. Gallup, B., and Dubowitz, V., Nature, 243, 287 (1973).

    Article  ADS  CAS  Google Scholar 

  3. McComas, A. J., Sica, R. E. P., and Currie, S., Nature, 226, 1263 (1964).

    Article  ADS  Google Scholar 

  4. Hathaway, P. W., Engel, W. K., and Zellweger, H., Archs Neurol., 22, 365 (1970).

    Article  CAS  Google Scholar 

  5. Rodan, S. B., Hintz, R. L., Sha'afi, R. I., and Rodan, G. A., Nature, 252, 589 (1974).

    Article  ADS  CAS  Google Scholar 

  6. Matheson, D. W., and Howland, J. L., Science, 184, 165 (1974).

    Article  ADS  CAS  Google Scholar 

  7. Roses, A. D., Herbstreith, M. H., and Appel, S. H., Nature, 254, 350 (1975).

    Article  ADS  CAS  Google Scholar 

  8. Weed, R. I., and Chailley, B., Nouvelle Rev. Francaise d'Hemat., 12, 775 (1972).

    CAS  Google Scholar 

  9. Mitchison, J. M., and Swann, M. M., J. exp. Biol., 31, 443 (1954).

    Google Scholar 

  10. Miller, M. E., Sem. Hematol., 12, 59 (1975).

    CAS  Google Scholar 

  11. Weed, R. I., LaCelle, P. L., Merrill, E. W., J. clin. Invest., 48, 795 (1969).

    Article  CAS  Google Scholar 

  12. Miller, M. E., Myers, K. A., Fedn Proc., 34, 269 (1975).

    Google Scholar 

  13. Wins, P., and Schoffeniels, E., Biochim. biophys. Acta, 120, 341 (1966).

    Article  CAS  Google Scholar 

  14. Rosenthal, A. S., Kregenow, F. M., and Moses, H. L., Biochim. biophys. Acta, 196, 254 (1970).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Charles R. Drew Postgraduate Medical School, Los Angeles, California, 90059

    ALAN K. PERCY & MICHAEL E. MILLER

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  1. ALAN K. PERCY
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  2. MICHAEL E. MILLER
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PERCY, A., MILLER, M. Reduced deformability of erythrocyte membranes from patients with Duchenne muscular dystrophy. Nature 258, 147–148 (1975). https://doi.org/10.1038/258147a0

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  • DOI: https://doi.org/10.1038/258147a0

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