Abstract
A model for the evolution of insulin mainly in terms of adaptive processes is discussed. The model depends critically on the relationship of sequence changes to the three-dimensional structure and the role of various parts of this structure in the conversion of the proinsulin molecule to the active form, the storage of insulin, its transport to the site of action and its interaction with a receptor.
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References
Darwinian, Neo-Darwinian Evolution, Proc. sixth Berkeley Symp., 5, (edit. by Le Cam, L. M., Neyman, J., and Scott, E. L.) (University of California Press, Berkeley and Los Angeles, 1972).
Smith, E. L., in The Enzymes (edit. by Boyer, P. D.), 1, 267–314 (Academic New York, 1970).
Kimura, M., Nature, 217, 624–626 (1968).
King, J. L., and Jukes, T. H., Science, 164, 788–798 (1969).
Markussen, J., and Volund, A., Int. J. Peptide Protein Res., 6, 79–86 (1974).
Smith, L. F., Diabetes, 21, Suppl. 2, 457–460 (1972).
Adams, M. J., et al., Nature, 224, 491–495 (1969).
Blundell, T. L., Dodson, G. G., Dodson, E. J., Hodgkin, D. C., and Vijayan, M., Rec. Prog. Hormone Res., 27, 1–40 (1971).
Blundell, T. L., Dodson, G. G., Hodgkin, D. C., and Mercola, D. A., Adv. Protein Chem., 26, 279–402 (1972).
Steiner, D. F., and Oyer, P. E., Proc. natn. Acad. Sci. U.S.A., 57, 473–480 (1967).
Grieder, M. H., Howell, S. L., and Lacy, P. E., J. Cell Biol., 41, 162–166 (1969).
Lange, R. H., Diabetologia, 7, 465–466 (1971).
Gavin, J. R., III, Gorden, P., Roth, J., Archer, J. A., Buell, D. N., J. biol. Chem., 248, 2202–2207 (1973).
Gammettoft, S., and Gliemann, J., Biochem. biophys. Acta, 320, 16–32 (1973).
Preychett, P., Roth, J., and Neville, D. M., Proc. natn. Acad. Sci. U.S.A., 68, 1833–1837 (1971).
Falkmer, S., in Ostman, J., Diabetes, Proc. sixth Cong. Int. Diabetes Fed., 55–66 (Excerpta Medica Foundation, Amsterdam, 1969).
Frank, B. H., and Veros, A. J., Biochem. biophys. Res. Commun., 38, 284–289 (1970).
Grant, P. T., Coombs, T. L., and Franks, B. H., Biochem. J., 126, 433 (1972).
Baker, E. N., and Dodson, G. G., J. molec. Biol., 54, 605 (1970).
Cutfield, J. F., Cutfield, S. M., Dodson, E. J., Dodson, G. G., and Sabesan, M. N., J. molec. Biol., 87, 23–30 (1974).
Peterson, J. D., Coulter, C. L., Steiner, D. F., Emdin, S. O., and Falkmer, S., Nature, 251, 239–240 (1974).
Zimmerman, A. E., and Yip, C. C., J. biol. Chem., 249, 4021–4036 (1974).
Wood, S. P., Blundell, T. L., Wollmer, A., Lazarus, N. R., and Neville, R. W. J., Eur. J. Biochem. (in the press).
Neville, R. W. J., Weir, B. J., and Lazarus, N. R., Diabetes, 22, 851–853 (1973).
Dayhoff, M. O., Atlas of Protein Sequence and Structure, 5, D210–D211 (1972).
Markussen, J., and Sunby, F., Int. J. Peptide Protein Res., 5, 37–38 (1973).
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Blundell, T., Wood, S. Is the evolution of insulin Darwinian or due to selectively neutral mutation?. Nature 257, 197–203 (1975). https://doi.org/10.1038/257197a0
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DOI: https://doi.org/10.1038/257197a0
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