Skip to main content
SpringerLink
Log in

E. coli membrane lipid alteration affecting T4 capsid morphogenesis

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

An Escherichia coli mutant, hd B3-1, cold sensitive for T4+ capsid assembly is described. The hd B3-1 character seems to be caused by altered lipid components of the bacterial inner membrane. The genetic locus for the hd B3-1 phenotype is designated fat A and is closely linked to proline.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Simon, L. D., Proc. natn. Acad. Sci. U.S.A., 69, 907–911 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Takano, T., and Kakefuda, T., Nature new Biol., 239, 34–37 (1972).

    Article  CAS  Google Scholar 

  3. Coppo, A., Manzi, A., Pulitzer, J. F., and Takahashi, H., J. molec. Biol., 76, 61–87 (1973).

    Article  CAS  Google Scholar 

  4. Georgopolous, C. P., Hendrix, R. W., Kaiser, A. D., and Wood, W. B., Nature new Biol., 239, 38–41 (1972).

    Article  Google Scholar 

  5. Laemmli, U. K., Beguin, F., and Gujer-Kellenberger, G., J. molec. Biol., 47, 69–85 (1970).

    Article  CAS  Google Scholar 

  6. Osborn, M. J., Gander, J. E., Parisi, E., and Carson, J., J. biol. Chem., 247, 3962–3972 (1972).

    CAS  PubMed  Google Scholar 

  7. Heinz, H., and Sturdervant, J., J. biol. Chem., 247, 6071–6075 (1972).

    Google Scholar 

  8. Shimshick, E. J., and McConnell, H. M., Biochemistry, 12, 2351–2360 (1973).

    Article  CAS  Google Scholar 

  9. Linden, C. D., Wright, K. L., McConnell, H. M., and Fox, C. F., Proc. natn. Acad. Sci. U.S.A., 70, 2271–2275 (1973).

    Article  ADS  CAS  Google Scholar 

  10. Sackmann, E., Trauble, H., Galla, H. J., and Overath, P., Biochemistry, 12, 5360–5369 (1973).

    Article  CAS  Google Scholar 

  11. Bligh, E. J., and Dyer, W. J., Can. J. biochem. Physiol., 37, 911–917 (1959).

    Article  CAS  Google Scholar 

  12. Dittmer, J. C., and Lester, R. L., J. lipid Res., 5, 126–127 (1964).

    CAS  PubMed  Google Scholar 

  13. Cronan, Jr., J. E., and Vagelos, P. R., Biochim. biophys. Acta, 265, 25–60 (1972).

    Article  CAS  Google Scholar 

  14. Ackman, R. G., in Methods in Enzymology, 14, (edit. by Lowenstein, J. M.), 329–381 (Academic, New York, 1969).

    Google Scholar 

  15. Kanemasa, Y., Akamatsu, Y., and Nojima, S., Biochim. biophys. Acta, 144, 382–390 (1967).

    Article  CAS  Google Scholar 

  16. Weintraub, S. B., and Frankel, F. R., J. molec. Biol., 70, 589–615 (1972).

    Article  CAS  Google Scholar 

  17. Merlie, J. P., Biochimie, 56, 717–728 (1974).

    Article  CAS  Google Scholar 

  18. Grisham, C., and Barnett, R., Biochemistry, 12, 2635–2637 (1973).

    Article  CAS  Google Scholar 

  19. Dittmer, J. C., and Wells, M. A., in Methods in Enzymology, 14, (edit. by Lowenstein, J. M.), 482–530 (Academic, New York, 1969).

    Google Scholar 

  20. Waggoner, A., Kingzett, T., Rottschaefer, S., and Griffith, O., Chem. phys. Lipids, 3, 245 (1969).

    Article  CAS  Google Scholar 

  21. Klein, K., Steinberg, R., Fiethen, B., and Overath, P., Eur. J. Biochem., 19, 442 (1971).

    Article  CAS  Google Scholar 

  22. Laemmli, U. K., Nature, 227, 680 (1970).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Dale Snover

    Present address: The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, 17033

  2. Charles Grisham

    Present address: Department of Chemistry, University of Virginia, Charlottesville, Virginia, 22901

Authors and Affiliations

  1. The Institute for Cancer Research, The Fox Chase Center for Cancer and Medical Sciences, Philadelphia, Pennsylvania, 19111

    Lee D. Simon, Thomas J. M. McLaughlin, Dale Snover, Jonathan Ou, Charles Grisham & Marilyn Loeb

Authors
  1. Lee D. Simon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas J. M. McLaughlin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dale Snover
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jonathan Ou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Charles Grisham
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marilyn Loeb
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Simon, L., McLaughlin, T., Snover, D. et al. E. coli membrane lipid alteration affecting T4 capsid morphogenesis. Nature 256, 379–383 (1975). https://doi.org/10.1038/256379a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/256379a0

  • Springer Nature Limited

This article is cited by

Search

Navigation