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Induction of erythroid leukaemia by Harvey and Kirsten sarcoma viruses

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Abstract

SEVERAL RNA tumour viruses including the Friend1, Rauscher2 and Kirsten (MLV-Ki)3 strains cause erythroid leukaemia in mice. These agents do not transform cells in vitro, but provide a helper activity for the replication of defective transforming sarcoma viruses. The Kirsten sarcoma virus (KiSV)4 was isolated from a rat inoculated with MLV-Ki, whereas the Harvey sarcoma virus (HaSV)5 was recovered from a rat infected with the non-transforming Moloney leukaemia helper virus (MLV-M)6. Both sarcoma viruses contain common rat genetic sequences7,8.

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Authors and Affiliations

  1. Hematology and Oncology Division, Children's Hospital Medical Centre and Sidney Farber Cancer Center, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115

    CHARLES D. SCHER

  2. Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland, 20014

    EDWARD M. SCOLNICK

  3. Martin Luther King, Jr Hospital, Los Angeles, California, 90059

    RICHARD SIEGLER

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  1. CHARLES D. SCHER
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  2. EDWARD M. SCOLNICK
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  3. RICHARD SIEGLER
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SCHER, C., SCOLNICK, E. & SIEGLER, R. Induction of erythroid leukaemia by Harvey and Kirsten sarcoma viruses. Nature 256, 225–226 (1975). https://doi.org/10.1038/256225a0

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  • DOI: https://doi.org/10.1038/256225a0

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