Abstract
FOREIGN bodies, including microorganisms, ingested by cultured mouse peritoneal macrophages become enclosed within phagosomes. Usually lysosome granules promptly assemble close to the phagosomes and fuse with their membranes, exposing the ingested objects to digestive enzymes1–3. Much of the kinetics of phagosome–lysosome fusion and degranulation in leukocytes was described by Robineaux, Hirsch, Cohn and their co-workers4–7, but the mechanisms and factors controlling them are only now beginning to emerge8,9.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Trouet, A., Bruxelles-Médical, Rev. Belge Sci. Méd. Chir., 46, 1139–1144 (1966).
Axline, S. G., and Cohn, Z. A., J. exp. Med., 131, 1239–1260 (1970).
Jensen, M. S., and Bainton, D. F., J. Cell Biol., 56, 379–388 (1973).
Robineaux, J., and Frederic, J., C. r. Soc. Biologie, 149, 486–489 (1955).
Hirsch, J. G., and Cohn, Z. A., J. exp. Med., 112, 1005–1014 (1960).
Hirsch, J. G., J. exp. Med., 116, 827–834 (1962).
Cohn, Z. A., and Wiener, E., J. exp. Med., 118, 1009–1020 (1963).
Poste, G., and Allison, A. C., Biochim. biophys. Acta, 300, 421–465 (1973).
Ahkong, Q. F., Fisher, D., Tampion, W., and Lucy, J. A., Nature, 253, 194–195 (1975).
Armstrong, J. A., and Hart, P. D'Arcy, J. exp. Med., 134, 713–740 (1971).
Jones, T. C., and Hirsch, J. G., J. exp. Med., 136, 1173–1194 (1972).
Jones, T. C., J. reticuloendothel. Soc. 15, 439–450 (1974).
Jones, T. C., Len, L., and Hirsch, J. G., J. exp. Med., 141, 466–482 (1975).
Armstrong, J. A., and Hart, P. D'Arcy, J. exp. Med. (in the press).
Allison, A. C., and Young, M. R., Life Sci., 3, 1407–1414 (1964).
Robbins, E., Marcus, P. I., and Gonatas, N. K., J. Cell Biol., 21, 49–62 (1964).
Hart, P. D'Arcy, Science, 162, 686–689 (1968).
Rees, R. J. W., and Hart, P. D'Arcy, Tubercle, 37, 327–332 (1956).
Hirsch, J. G., and Fedorko, M. E., J. Cell. Biol., 38, 615–627 (1968).
Dumont, A., and Robert, A., Lab. Invest., 23, 278–286 (1970).
Belcher, R. W., Carney, J. F., and Monahan, F. G., Lab. Invest., 29, 620–627 (1973).
Williamson, J., in The African Trypanosomiases, 172–174 (Allen and Unwin, London, 1970).
Eisen, V., and Loveday, C., Br. J. Pharmac., 49, 678–687 (1973).
Fortes, P. A. G., Ellory, J. C., and Lew, V. L., Biochim. biophys. Acta, 318, 262–272 (1973).
de Duve, C., et al., Biochem. Pharmac., 23, 2495–2531 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HART, P., YOUNG, M. Interference with normal phagosome-lysosome fusion in macrophages, using ingested yeast cells and suramin. Nature 256, 47–49 (1975). https://doi.org/10.1038/256047a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/256047a0
- Springer Nature Limited
This article is cited by
-
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
Nature (2000)
-
Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages
Lipids (1996)
-
Suramin-induced mucopolysaccharidosis in rat incisor
Cell and Tissue Research (1993)
-
In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of murine peritoneal macrophages
Mycopathologia (1992)
-
Effects of suramin on phagocytes in vitro
Annals of Hematology (1991)