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Growth inhibition of animal cells by succinylated concanavalin A

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Abstract

A non-agglutinating lectin preparation, succinyl-con A, inhibits the growth of untransformed 3T3 mouse fibroblasts in a manner that mimics density-dependent growth inhibition. The growth inhibitory interaction between succinyl-con A and cells occurs exclusively during the mitotic and/or early G1 phase of the cell cycle.

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Authors and Affiliations

  1. Department of Biochemistry, Biocenter, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland

    Raphael J. Mannino & Max M. Burger

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  1. Raphael J. Mannino
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  2. Max M. Burger
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Mannino, R., Burger, M. Growth inhibition of animal cells by succinylated concanavalin A. Nature 256, 19–22 (1975). https://doi.org/10.1038/256019a0

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  • DOI: https://doi.org/10.1038/256019a0

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