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Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium

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Abstract

CHLORINATED hydrocarbons, such as vinyl chloride or vinylidene chloride (1,1-dichloroethylene), are produced in large quantities and are present in the environment1. Recently, vinyl chloride monomer has been shown to be carcinogenic in animals and man2–4 and mutagenic in microbial systems5–7. Vinylidene chloride (VDC), a structurally related substance and co-polymer of vinyl chloride, is used in the manufacture of plastics8; it could also occur as a decomposition product of 1,1,1-trichloroethane1. Another chemically related compound, 2-chlorobutadiene (chloroprene), has been used in the manufacture of synthetic rubber since 1930.

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Authors and Affiliations

  1. Unit of Chemical Carcinogenesis, International Agency for Research on Cancer, 150, Cours Albert Thomas, 69008, Lyon, France

    HELMUT BARTSCH, CHRISTIAN MALAVEILLE, RUGGERO MONTESANO & LORENZO TOMATIS

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  1. HELMUT BARTSCH
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  2. CHRISTIAN MALAVEILLE
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  3. RUGGERO MONTESANO
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  4. LORENZO TOMATIS
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BARTSCH, H., MALAVEILLE, C., MONTESANO, R. et al. Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium. Nature 255, 641–643 (1975). https://doi.org/10.1038/255641a0

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  • DOI: https://doi.org/10.1038/255641a0

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