Abstract
ONE of the major deficiencies in cancer medicine is the inability to detect low level malignant growth such as tumours at an early stage of development or residual malignant growth after therapy. Biochemical assays for malignancy have centred around carcinoembryonic antigen (CEA) and α-foetoprotein (AFP)1, both of which are proteins found normally in embryonic tissues and only at low levels in mature, normal adults. Adult human serum contains a set of proteins with affinity for DNA2 and, as we report here, foetal human serum contains additional DNA-binding proteins not observed in adult sera. Patients with a wide variety of malignant disorders have been assayed for their complement of serum DNA-binding proteins; foetal species were present in the majority of sera examined.
Similar content being viewed by others
References
Laurence, D. J. R., and Neville, A. M., Br. J. Cancer, 26, 335–355 (1972).
Brehm, S. P., Hoch, S. O., and Hoch, J. A., Biochem. biophys. Res. Commun., 63, 24–31 (1975).
Laemmli, U. K., Nature, 227, 680–685 (1970).
Thomson, D. M. P., Krupey, J., Freedman, S. O., and Gold, P., Proc. natn. Acad. Sci. U.S.A., 64, 161–167 (1969).
MacSween, J. M., Warner, N. L., Bankhurst, A. D., and Mackay, I. R., Br. J. Cancer, 26, 356–360 (1972).
Matsumoto, Y., Suzuki, T., Ono, H., Nakase, A., and Honjo, I., Cancer, 34, 1602–1606 (1974).
Kubinski, H., and Javid, H., Science, 182, 296–297 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HOCH, S., LONGMIRE, R. & HOCH, J. Unique DNA-binding protein in the serum of patients with various neoplasms. Nature 255, 560–562 (1975). https://doi.org/10.1038/255560a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/255560a0
- Springer Nature Limited
This article is cited by
-
Anti-DNA antibodies
Clinical Reviews in Allergy (1994)
-
DNA-binding proteins in the sera of patients with malignant melanoma
Archives of Dermatological Research (1979)