Abstract
IN favourable conditions hosts can produce antibodies to components of their tumours. An intriguing example is the ability of BALB/c mice immunised with syngeneic myeloma proteins MOPC 315 or MOPC 460 (ref. 1) to make antibodies to the idiotypic determinants of these proteins. The sensitised mice reject tumour-producing MOPC 315 or MOPC 460 cells; this may result from reaction of anti-idiotypic antibodies with myeloma proteins on myeloma cell surfaces. On the assumption that any substance able to bind to a cell membrane surface component could modify the rate of cell division, we hoped to inhibit myeloma growth by injecting specific antigen into the hosts. This plan was based on the observation that specific antigen binds to the cell surface of antibody-secreting myeloma cells2. We describe here the inhibition of the growth of plasmacytoma TEPC 15 by the specific pneumococcus C polysaccharide (PCP) antigen.
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PARAF, A., GUERIN-MARCHAND, C., AUBRY, J. et al. Inhibition of murine plasmacytoma TEPC 15 by its specific antigen. Nature 255, 488–489 (1975). https://doi.org/10.1038/255488a0
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DOI: https://doi.org/10.1038/255488a0
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