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Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour

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Abstract

ALTHOUGH cerebral vascular accident or stroke is a frequent clinical problem, there has been little systematic research into the cause of the common behavioural consequences such as emotional lability, depression and motor and cognitive deficits. Ischaemic brain injury affects the content and metabolism of brain catecholamines in rats1, monkeys and gerbils2, as well as the concentration of monoamines in human cerebrospinal fluid3. In an attempt to study experimental stroke, we have occluded surgically the middle cerebral artery in rats and found, during the 40-d postoperative period, changes in both behaviour and brain catecholamines.

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Authors and Affiliations

  1. Laboratory of Neuropharmacology, National Institute of Mental Health, St Elizabeth's Hospital, Washington, DC, 20032

    ROBERT G. ROBINSON, WILLIAM J. SHOEMAKER, MARGRET SCHLUMPF, THOMAS VALK & FLOYD E. BLOOM

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  1. ROBERT G. ROBINSON
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  2. WILLIAM J. SHOEMAKER
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  3. MARGRET SCHLUMPF
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  4. THOMAS VALK
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  5. FLOYD E. BLOOM
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ROBINSON, R., SHOEMAKER, W., SCHLUMPF, M. et al. Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour. Nature 255, 332–334 (1975). https://doi.org/10.1038/255332a0

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  • DOI: https://doi.org/10.1038/255332a0

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