Abstract
GROWTH hormone (GH) and pituitary prolactin (PP) are structurally homologous and have functional similarities both in the lower vertebrates1 and in mammals2. In the whole animal a major function of GH is to stimulate the longitudinal growth of the skeleton, and GH acts by controlling the production of a second series of hormones, the somatomedins. The somatomedins are present in serum and will stimulate the rates of division and matrix production of chondrocytes in vitro3,4. GH itself has no effect in vitro on the cartilage cells, the chondrocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Nicoll, C. S., and Licht, P., Gen. comp. Endocr., 27, 490–507 (1971).
Denko, C. W., Endocrinology, 65, 147–151 (1959).
Daughaday, W. H., Adv. Int. Med., 17, 237–263 (1971).
Hall, K., and Van Wyk, J. J., Curr. Top. exp. Endocr., 2, 155–178 (1974).
McConaghey, P. J., Endocrinology, 52, 1–9 (1972).
McConaghey, P., and Dehnel, J. M., J. Endocr., 52, 587–588 (1972).
Wu, A., Grant, D. B., Hambley, J., and Levi, A. J., Clin. Sci. molec. Med., 47, 359–366 (1974).
Dehnel, J. M., McConaghey, P., and Francis, M. J. O., J. Endocr., 62, 355–361 (1974).
Dehnel, J. M., thesis, Oxford Univ. (1974).
Ash, P., and Francis, M. J. O., J. Endocr. (in the press).
Waymouth, C. J., Natn. Cancer Inst., 22, 1003–1017 (1959).
Reichert, L. E., and Wilhelmi, A. E., Endocrinology, 92, 1301–1304 (1973).
Gordon, A. H., in Laboratory Techniques in Biochemistry and Molecular Biology, 1 (edit. by Work, T. S., and Work, E.), 1–145 (North-Holland, London, 1969).
Joseph, M. M., and Meier, A. H., Proc. Soc. exp. Biol. Med., 146, 1150–1155 (1974).
Meier, A. H., Gen. comp. Endocr., suppl., 3, 499–508 (1972).
Hall, K., Acta Endocr., 63, 338–350 (1970).
Ellis, S., Lorenson, M., Grindeland, R. E., and Callahan, P. X., Proc. second Int. Cong. Growth & Growth Hormone, Excerpta Med. Cong. Series, 244, 55–67 (1972).
Weldon, U. U., Jacobs, L. S., Pagliara, A. S., and Daughaday, W. H., Proc. Fourth Int. Cong. Endocr., Excerpta Med. Cong. Series, 256, 16–21 (1972).
Finkelstein, J. W., Kream, J., Ludan, A., and Hellman, L., J. clin. Endocr., 35, 13–17 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FRANCIS, M., HILL, D. Prolactin-stimulated production of somatomedin by rat liver. Nature 255, 167–168 (1975). https://doi.org/10.1038/255167a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/255167a0
- Springer Nature Limited
This article is cited by
-
The effect of acute and chronic insulin administration on insulin-like growth factor-I expression in the pituitary-intact and hypophysectomised rat
Diabetologia (1989)
-
Interaction between endocrine and paracrine peptides in prenatal growth control
European Journal of Pediatrics (1987)
-
Long-term follow-up of children with craniopharyngioma
European Journal of Pediatrics (1984)
-
Ultrastructure of pituitary somatotrophs of male rats during liver carcinogenesis by 3′-methyl-4-dimethylaminoazobenzene
Virchows Archiv B Cell Pathology Including Molecular Pathology (1984)
-
Specific uptake of human growth hormone by the liver of severely hypothyroid rats
Journal of Endocrinological Investigation (1981)