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Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems

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Abstract

THE rapid, naturally occurring aggregation shown by limpet haemocytes1 and mammalian blood platelets2,3 is accompanied by production of prominent microspikes1,3 and is reversibly inhibited by cytochalasin B (CB)4,5, thus differing from the slower aggregation of dissociated tissue cells6–8. Although CB inhibits aggregation of limpet haemocytes in shaken suspension, preformed aggregates shaken in the presence of CB are not disrupted, suggesting that CB inhibits the formation of stable contacts5.

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Authors and Affiliations

  1. Department of Experimental Pathology, Charing Cross Hospital Medical School, London, W6

    T. PARTRIDGE

  2. Department of Biology, Queen Elizabeth College, London, W7 8AH, UK

    G. E. JONES & R. GILLETT

Authors
  1. T. PARTRIDGE
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  2. G. E. JONES
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  3. R. GILLETT
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PARTRIDGE, T., JONES, G. & GILLETT, R. Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems. Nature 253, 632–634 (1975). https://doi.org/10.1038/253632a0

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  • DOI: https://doi.org/10.1038/253632a0

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