Abstract
CELLS of the slime mould Dictyostelium discoideum aggregate around centres into multicellular fruiting bodies as a chemotactic response to cyclic AMP (refs 1 and 2). The wave-like character of this phenomenon suggests the release of cyclic AMP pulses by the founder cells3,4. In this respect, metabolic oscillations controlled by cyclic AMP have been observed in suspension cultures of D. discoideum cells capable of forming aggregates5. We present here a mechanism for both these intracellular oscillations and the periodic release of chemotactic signal by aggregation centres.
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References
Konijn, T. M., van de Meene, J. G. C., Bonner, J. T., and Barkley, D. S., Proc natn. Acad. Sci. USA, 58, 1152–1154 (1967).
Bonner, J. T., A. Rev. Microbiol., 25, 75–92 (1971).
Shaffer, B. M., Am. Nat., 91, 19–35 (1957).
Gerisch, G., Current Topics in Developmental Biology, 3, 157–197 (1968).
Gerisch, G., and Hess, B., Proc. natn. Acad. Sci. USA, 71, 2118–2122 (1974).
Rossomando, E. F., and Sussman, M., Proc. natn. Acad. Sci. USA, 70, 1254–1257 (1973).
Malchow, D., Nägele, B., Schwarz, H., and Gerisch, G., Eur. J. Bichem., 28, 136–142 (1972).
Monod, J., Wyman, J., and Changeux, J. P., J. molec. Biol., 12, 88–118 (1965).
Dalziel, K., FEBS Lett., 1, 346–348 (1968).
Goldbeter, A., and Lefever, R., Biophys J., 12, 1302–1315 (1972).
Nicolis, G., Adv. chem. Phys., 19, 209–324 (1971).
Glansdorff, P., and Prigogine, I., Thermodynamic Theory of Structure, Stability and Fluctuations (Wiley, New York, 1971).
Goldbeter, A., and Nicolis, G., Progr.theor. Biol. (in the press).
Hess, B., Boiteux, A., and Kruger, J., Adv. Enzyme Regul., 7, 149–167 (1969).
Baumann, P., and Wright, B., Biochemistry, 7, 3653–3661 (1968).
Durston, A. J., Devl Biol., 38, 308–319 (1974).
Gerisch, G., Naturwisscnschaften, 58, 430–438 (1971).
Robertson, A., and Cohen, M. H., A. Rev. biophys. Bioeng., 1, 409–464 (1972).
Cohen, M. H., and Robertson, A., J. theor. Biol., 31, 101–118 (1971).
Keller, E. F., and Segel, L. A., J. theor. Biol., 26, 399–415 (1970).
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GOLDBETER, A. Mechanism for oscillatory synthesis of cyclic AMP in Dictyostelium discoideum. Nature 253, 540–542 (1975). https://doi.org/10.1038/253540a0
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DOI: https://doi.org/10.1038/253540a0
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