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Inhibition of rat lymph node cell cytotoxicity by hepatoma-associated embryonic antigen

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Abstract

ONE feature frequently accompanying malignant transformation is the re-expression of embryonic characteristics, and the presence of tumour-associated embryonic antigens has been demonstrated on a wide range of experimental and human tumours1–5. Studies in our laboratory, using aminazo-dye-induced rat hepatomas, have shown that these re-expressed antigens are detectable on cells derived from 14–16-d-old rat embryos, but not cells from adult rat tissue1,6 and in vitro microcytotoxicity tests have revealed that rats bearing transplanted hepatomas exhibit a cell-mediated immune reaction against the embryonic antigen (EA)6.

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Authors and Affiliations

  1. Cancer Research Campaign Laboratories, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

    R. C. REES, M. R. PRICE, R. W. BALDWIN & L. P. SHAH

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  1. R. C. REES
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  2. M. R. PRICE
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  3. R. W. BALDWIN
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  4. L. P. SHAH
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REES, R., PRICE, M., BALDWIN, R. et al. Inhibition of rat lymph node cell cytotoxicity by hepatoma-associated embryonic antigen. Nature 252, 751–753 (1974). https://doi.org/10.1038/252751a0

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  • DOI: https://doi.org/10.1038/252751a0

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