Skip to main content
SpringerLink
Log in

Tolerance induction with bovine γ globulin in mouse radiation chimaeras depends on macrophages

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE injection of adult mice with ultracentrifuged heterologous γ globulin induces immunological unresponsiveness to a subsequent injection of the globulin incorporated in incomplete or complete Freund's adjuvant1. It has been reported that inbred strains of mice differ in their susceptibility to the induction of unresponsiveness. Bovine γ globulin (BGG), human γ globulin (HGG) and rabbit γ globulin (RGG) easily produce tolerance in C57BL/6 and DBA/2 mice but not in BALB/c mice2,3. Passage of BGG through the circulation of BALB/c mice (but not DBA/2 mice) gives preparations which produce a high degree of tolerance in the recipient mice suggesting that strain differences in the induction of tolerance are related to the capacity of the reticuloendothelial system to process the immunogenic component in ultracentrifuged soluble BGG (sBGG). Here, we report that the administration of carrageenin, which is known to be toxic for macrophages destroys the resistance to tolerance induction in BALB/c mice. Also spleen and bone marrow cells transferred from BALB/c mice to irradiated DBA/2 mice to form chimaeras, do not show characteristic BALB/c resistance to induction of tolerance until twelve weeks after transfer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dresser, D. W., Immunology, 5, 378–389 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Golub, E. S., and Weigle, W. O., J. Immun., 102, 389–396 (1969).

    CAS  PubMed  Google Scholar 

  3. Das, S., and Leskowitz, S., J. Immun., 105, 937–943 (1970).

    Google Scholar 

  4. Catanzaro, P. J., Schwartz, H. J., and Graham, R. C., Am. J. Path., 64, 387–405 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Allison, A. C., Harington, J. S., and Birbeck, N., J. exp. Med., 124, 141–155 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hanna, N., and Leskowitz, S., Cell. Immun., 7, 189–197 (1973).

    Article  CAS  Google Scholar 

  7. Cudkowicz, G., and Bennett, M., J. exp. Med., 134, 83–103 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kumar, V., Bennett, M., and Eckner, R. J., J. exp. Med., 139, 1093–1110 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Das, S., and Leskowitz, S., J. Immun., 112, 107–114 (1974).

    CAS  PubMed  Google Scholar 

  10. Unanue, E. R., Adv. Immun., 15, 95–167 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. Balner, H., Transplantation, 1, 217–223 (1963).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Immunology Research Center, University of Belgrade, Vojvode Stepe 458, 11000, Belgrade, Yugoslavia

    MIODRAG L. LUKIC

  2. Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, 02111

    SIDNEY LESKOWITZ

Authors
  1. MIODRAG L. LUKIC
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. SIDNEY LESKOWITZ
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LUKIC, M., LESKOWITZ, S. Tolerance induction with bovine γ globulin in mouse radiation chimaeras depends on macrophages. Nature 252, 605–607 (1974). https://doi.org/10.1038/252605a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252605a0

  • Springer Nature Limited

This article is cited by

Search

Navigation