Skip to main content
SpringerLink
Log in

Antibody-dependent cell-mediated damage to schistosomula in vitro

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many in vitro models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts1–6. Similar responses could also be involved in protective immunity against metazoan parasites, and evidence for cell-mediated effector mechanisms of various types has emerged from work on Nippostrongylus braziliensis7 and Litomosoides carinii8 in rats. Here we present two new aspects of cell-mediated responses to metazoan parasites. First, we have adapted the 51Cr-release technique to assay damage to schistosomula of Schistosoma mansoni in vitro. Second, we provide evidence that normal human peripheral blood leukocytes, in the presence of sera from patients infected with S. mansoni, can damage labelled schistosomula in the absence of added complement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. MacLennan, I. C. M., and Harding, B., Immunology, 18, 405 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Perlmann, P., and Perlmann, H., Cell. Immun., 1, 300 (1970).

    Article  CAS  Google Scholar 

  3. Grant, C. K., Avis, P. J., Hall, J. G., and Alexander, P., Transplantation, 11, 356 (1971).

    Article  CAS  Google Scholar 

  4. Wunderlich, J. R., Rosenberg, E. B., and Connolly, J. M., in Progress in Immunology (edit. by Amos, B.) 473 (Academic Press, New York, 1971).

    Book  Google Scholar 

  5. MacLennan, I. C. M., Transplant. Rev., 13, 67 (1972).

    CAS  PubMed  Google Scholar 

  6. Allison, A. C., Ann. Inst. Pasteur, 122, 619 (1972).

    CAS  Google Scholar 

  7. Ogilvie, B. M., and Love, R. J., Transplant. Rev., 19, 147 (1974).

    CAS  PubMed  Google Scholar 

  8. Bagai, R. C., and Subrahmanyam, D., Nature, 228, 682 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Clegg, J. A., and Smithers, S. R., Int. J. Parasit., 2, 79 (1972).

    Article  CAS  Google Scholar 

  10. Bodmer, W., Tripp, M., and Bodmer, J., in Histocompatibility Testing (edit. by Curtoni, E. S., et al.) 341 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  11. Martin, L., and Beaver, P. C., Am. J. trop. Med. Hyg., 17, 382 (1968).

    Article  CAS  Google Scholar 

  12. Butterworth, A. E., Cell. Immun. (in the press).

  13. Dean, D. A., Wistar, R., and Murrell, K. D., Am. J. trop. Med. Hyg., 23, 420 (1974).

    Article  CAS  Google Scholar 

  14. Smithers, S. R., in Immunology of Parasitic Infections (edit. by Cohen, S., and Sadun, E. H.) (Blackwell Scientific Publications, Oxford, in the press).

Download references

Author information

Authors and Affiliations

  1. Wellcome Trust Research Laboratories, PO Box 43640, Nairobi

    A. E. BUTTERWORTH, R. F. STURROCK & V. HOUBA

  2. Department of Medicine, University of Nairobi, Nairobi, Kenya

    P. H. REES

Authors
  1. A. E. BUTTERWORTH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. F. STURROCK
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. HOUBA
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. H. REES
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BUTTERWORTH, A., STURROCK, R., HOUBA, V. et al. Antibody-dependent cell-mediated damage to schistosomula in vitro. Nature 252, 503–505 (1974). https://doi.org/10.1038/252503a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252503a0

  • Springer Nature Limited

This article is cited by

Search

Navigation