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In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens

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Abstract

MANY natural and synthetic chemicals in the environment may be carcinogenic, but it is clearly impracticable to assess the potential hazard from all such compounds by existing in vivo methods. Simple preliminary screening procedures are therefore urgently needed to identify the compounds most likely to be hazardous and allow detailed study of these suspected carcinogens. A series of fundamentally different test systems involving a range of biological materials will probably be necessary. As most carcinogens seem to act through active metabolites produced by the enzymes of mammalian endoplasmic reticulum1, any test system probably requires the presence of these enzymes and the cofactor NADPH2.

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Authors and Affiliations

  1. Department of Biochemistry, University of Surrey, Guildford, GU2 5XH, Surrey, UK

    F. MCPHERSON, J. W. BRIDGES & D. V. PARKE

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  1. F. MCPHERSON
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  2. J. W. BRIDGES
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  3. D. V. PARKE
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MCPHERSON, F., BRIDGES, J. & PARKE, D. In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens. Nature 252, 488–489 (1974). https://doi.org/10.1038/252488a0

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