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Fluorocarbon anaesthetics break hydrogen bonds

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Abstract

MANY fluorocarbon derivatives that contain higher halogens dissociate hydrogen bonds of the N–H—N, O–H—O, S–H—S, N–H—O=C type which are similar to those occurring in living organisms. A parallelism exists between this property of fluorocarbons and their anaesthetic potency. Their interference with cell division might also be related to it.

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Authors and Affiliations

  1. Département de Chimie, Université de Montréal, Montréal, Québec, Canada

    THERESE DI PAOLO & C. SANDORFY

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  1. THERESE DI PAOLO
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  2. C. SANDORFY
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DI PAOLO, T., SANDORFY, C. Fluorocarbon anaesthetics break hydrogen bonds. Nature 252, 471–472 (1974). https://doi.org/10.1038/252471a0

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  • DOI: https://doi.org/10.1038/252471a0

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