Skip to main content
SpringerLink
Log in

Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE ability of prostaglandins to affect platelet function has been described in many laboratories1,2. The most potent of these, prostaglandin E1 (PGE1), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E2 (PGE2), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined3 and the concentration of prostaglandin used4.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ball, G., Brereton, G. G., Fulwood, M., Ireland, D. M., and Yates, P., Biochem. J., 120, 709–718 (1970).

    Article  CAS  Google Scholar 

  2. Mills, D. C. B., and Smith, J. B., Biochem. J., 121, 185–196 (1971).

    Article  CAS  Google Scholar 

  3. Kloeze, J., in Prostaglandins (edit. by Bergstrom, S. and Samuelsson, B.) 241–252 (Almquist and Wiksell, Stockholm, 1967).

    Google Scholar 

  4. Salzman, E. W., New Engl. J. Med., 286, 358–363 (1972).

    Article  CAS  Google Scholar 

  5. Smith, J. B., and Willis, A. L., Nature new Biol., 231, 235–237 (1971).

    Article  CAS  Google Scholar 

  6. Droller, M. J., Proc. 15th Mtg Am. Soc. Hematol. (1972).

  7. Born, G. V. R., J. Physiol., Lond., 162, 67P–68P (1962).

    Google Scholar 

  8. Hirsh, J., Street, D., Cade, J. F., and Amy, H., Blood, 41, 369–377 (1973).

    CAS  PubMed  Google Scholar 

  9. Haslam, R. J., Nature, 202, 765–768 (1964).

    Article  ADS  CAS  Google Scholar 

  10. Wolfe, S. M., and Shulman, N. R., Biochem. biophys. Res. Commun., 35, 265–272 (1969).

    Article  CAS  Google Scholar 

  11. White, A. A., and Zenser, T. V., Analyt. Biochem., 41, 372–396 (1971).

    Article  CAS  Google Scholar 

  12. Ramachandran, J., Analyt. Biochem., 43, 227–239 (1971).

    Article  CAS  Google Scholar 

  13. Droller, M. J., and Wolfe, S. M., J. clin. Invest., 51, 3094–3103 (1972).

    Article  CAS  Google Scholar 

  14. Shio, H., and Ramwell, P. W., Nature new Biol., 236, 45–46 (1972).

    Article  CAS  Google Scholar 

  15. Droller, M. J., and Wolfe, S. M., New Engl. J. Med., 286, 948 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Syntex Research, Institute of Biological Sciences, Palo Alto, California, 94304

    JOHN J. BRUNO & LESLIE A. TAYLOR

  2. Stanford University Medical Center, Stanford, California, 94305

    MICHAEL J. DROLLER

Authors
  1. JOHN J. BRUNO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LESLIE A. TAYLOR
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. MICHAEL J. DROLLER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRUNO, J., TAYLOR, L. & DROLLER, M. Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation. Nature 251, 721–723 (1974). https://doi.org/10.1038/251721a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/251721a0

  • Springer Nature Limited

This article is cited by

Search

Navigation