Abstract
THE cytotoxic activity1,2 of immune thymus-derived lymphocytes (T cells) for 51Cr-labelled fibroblasts, or macrophages infected with lymphocytic choriomeningitis (LCM) virus is restricted by the H-2 gene complex3,4. Specific lysis of LCM-infected monolayer cultures occurs only when targets and overlaying, sensitised T cells share at least one set of H-2 antigenic specificities.
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References
Zinkernagel, R. M., and Doherty, P. C., Scand. J. Immun. (in the press).
Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., J. Immun., 112, 1548–1552 (1974).
Zinkernagel, R. M., and Doherty, P. C., Nature, 248, 701–702 (1974).
Doherty, P. C., and Zinkernagel, R. M., Transplant Rev., 19, 89–120 (1974).
Gilden, D. H., Cole, G. A., Monjan, A. A., and Nathanson, N., J. exp. Med., 135, 860–873 (1972).
Doherty, P. C., and Zinkernagel, R. M., J. Immun. (in the press).
Shearer, G. M., Eur. J. Immun. (in the press).
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ZINKERNAGEL, R., DOHERTY, P. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis. Nature 251, 547–548 (1974). https://doi.org/10.1038/251547a0
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DOI: https://doi.org/10.1038/251547a0
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