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Prostaglandin E1 action on sinus pacemaker and adenylyl cyclase in kitten myocardium

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Abstract

A QUANTUM mechanical analysis of Kier et al.1,2 indicates that the amine group of the catecholamine isoprenaline may not be essential to produce pharmacological effects mediated through adrenergic β receptors. Based on this and on conformational similarities between the ring, β-hydroxyl group and alkyl areas of N-n-propylnoradrenaline and prostaglandin (PG) E1, these authors predicted that PGE1 should be able to interact positively with adrenergic β receptors. Isolated tissues from kitten heart are appropriate systems to investigate effects of drugs which are β-receptor dependent and we tested the predictions of Kier et al. by investigating if PGE1 produced positive inotropic and chronotropic effects and whether these effects are transmitted through the adrenergic β receptors.

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Authors and Affiliations

  1. Centro de Investigacions Cardiologicas, M.T. de Alear 2270, Buenos Aires, Argentina

    A. J. KAUMANN

  2. Department of Physiology, Northwestern University Medical Center, Chicago, Illinois, 60611

    LUTZ BIRNBAUMER

Authors
  1. A. J. KAUMANN
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  2. LUTZ BIRNBAUMER
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KAUMANN, A., BIRNBAUMER, L. Prostaglandin E1 action on sinus pacemaker and adenylyl cyclase in kitten myocardium. Nature 251, 515–517 (1974). https://doi.org/10.1038/251515a0

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  • DOI: https://doi.org/10.1038/251515a0

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