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Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes

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Abstract

NERVE endings (synaptosomes) isolated from the mammalian hypothalamus contain the hypophysiotrophic hormones which regulate adenohypophysial function. Edwardson et al. have shown1 that release of these neurosecretory substances can be elicited from incubated hypothalamic synaptosomes by electrical or potassium stimulation and the release mechanism has been shown2 to be calcium dependent. We report here that steroid hormones administered both in vivo and in vitro and neurotransmitter substances given in vitro modulate the release of corticotrophin-releasing factor (CRF) from synaptosomes prepared from rat and sheep hypothalamus.

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References

  1. Edwardson, J. A., Bennett, G. W., and Bradford, H. F., Nature, 240, 554–556 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Bennett, G. W., and Edwardson, J. A., J. Endocr., 59, xv–xvi (1973).

    CAS  PubMed  Google Scholar 

  3. Bradford, H. F., Bennett, G. W., and Thomas, A. J., J. Neurochem., 21, 495–505 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. Gray, E. G., and Whittaker, V. P., J. Anat., 96, 79–88 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Rees, L. H., Cook, D. M., Kendall, J. W., Allen, C. F., Kramer, R. M., Ratcliffe, J. G., and Knight, R. A., Endocrinology, 89, 254–261 (1971).

    Article  CAS  PubMed  Google Scholar 

  6. Jones, M. T., Brush, F. R., and Neame, R. L. B., J. Endocr., 55, 489–497 (1972).

    Article  CAS  PubMed  Google Scholar 

  7. Kraulis, I., Traikov, H., Li, M. P., and Birmingham, M. K., J. Steroid Biochem., 4, 129–137 (1973).

    Article  CAS  PubMed  Google Scholar 

  8. Jones, M. T., Tiptaft, E. M., Brush, F. R., Fergusson, D. A. N., and Neame, R. L. B., J. Endocr., 60, 223–233 (1974).

    Article  CAS  PubMed  Google Scholar 

  9. Hedge, G. A., and Smelik, P. G., Science, 159, 891–892 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Steiner, F. A., Ruf, K., and Akert, K., Brain Res., 12, 74–85 (1969).

    Article  CAS  PubMed  Google Scholar 

  11. van Loon, G. R., Scapagnini, U., Moberg, G. P., and Ganong, W. F., Endocrinology, 89, 1464–1469 (1971).

    Article  CAS  PubMed  Google Scholar 

  12. Millhouse, E. W., Burden, J. L., and Jones, M. T., Neuroendocrinology (in the press).

  13. Fuxe, K., and Hökfelt, T., in Frontiers in Neuro endocrinology (edit. by Ganong, W. F., and Martini, L.) 47–96 (Oxford University Press, New York, 1969).

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Imperial College, London, SW7, UK

    J. A. EDWARDSON & G. W. BENNETT

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  1. J. A. EDWARDSON
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  2. G. W. BENNETT
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EDWARDSON, J., BENNETT, G. Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes. Nature 251, 425–427 (1974). https://doi.org/10.1038/251425a0

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  • DOI: https://doi.org/10.1038/251425a0

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