Abstract
AXELROD1 found that released noradrenaline is recaptured by presynaptic nerve terminals, and proposed reuptake as a mechanism for rapid neurotransmitter inactivation. Subsequent studies led to the identification of high and low-affinity components in the uptake of several putative neurotransmitters by nerve terminals2–7. Although the apparent Km values reported for the high-affinity uptake of some neurotransmitters (notably amino acids) are comparable to those reported for the low-affinity uptake of other neurotransmitters, it is generally thought that the inactivation of most neurotransmitter amino acids is obtained through high-affinity uptake systems having a Km of the order of 10−5 M. Indeed, the existence of a high-affinity uptake for a given substance is often considered to favour its being a neurotransmitter.
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References
Axelrod, J., Harvey Lect., 67, 175 (1973).
Iversen, L. L., in Biochemistry of simple neuronal models (edit. by Costa, E., and Giacobini, E.) 109 (Raven Press, New York, 1970).
Snyder, S. H., Kuhar, M. J., Green, A. I., Coyle, J. T., and Shaskan, E. G., Int. Rev. neurobiol., 13, 127 (1970).
Iversen, L. L., and Johnston, G. A. R., J. Neurochem., 18, 1939 (1971).
Johnston, G. A. R., and Iversen, L. L., J. Neurochem., 18, 1951 (1971).
Levi, G., and Raiteri, M., Life Sci. (part I) 12, 81 (1973).
Snyder, S. H., Young, A. B., Bennett, J. P., and Mulder, A. H., Fedn. Proc., 32, 2039 (1973).
Le Fevre, P. G., and McGinnis, G. F., J. gen. Physiol., 44, 87 (1960).
Heinz, E., A. Rev. Physiol., 29, 21 (1967).
Iversen, L. L., and Neal, M. J., J. Neurochem., 15, 1141 (1968).
Aprison, M. H., and McBride, W. J., Life Sci. (Part I) 12, 449 (1973).
Levi, G., Bertollini, A., Chen, J., and Raiteri, M., J. Pharmac. exp. Ther., 188, 429 (1974).
Gray, E. G., and Whittaker, V. P., J. Anat., 96, 79 (1962).
Raiteri, M., Angelini, F., and Levi, G., Eur. J. Pharmac., 25, 411 (1974).
Levi, G., Blasberg, R., and Lajtha, A., Archs Biochem. Biophys., 144, 339 (1966).
Crnic, D. M., Hammerstad, J. P., and Cutler, R. W. P., J. Neurochem., 20, 203 (1973).
Weinstein, H., Varon, S., Muhleman, D., and Roberts, E., Biochem. Pharmac., 14, 273 (1965).
Martin, D. L., J. Neurochem., 21, 345 (1973).
Levi, G., Archs. Biochem. Biophys., 151, 8 (1972).
Aprison, M. H., Davidoff, R. A., and Werman, R., in Handbook of Neurochemistry (edit. by Lajtha, A.) III, 281 (Plenum Press, New York, 1970).
Curtis, D. R., and Johnson, G. A. R., in Handbook of Neurochemistry (edit. by Lajtha, A.) IV, 115 (Plenum Press, New York, 1970).
Henn, F., Hamberger, A., Proc. natn. Acad. Sci., U.S.A., 68, 2686 (1971).
Schon, F., and Kelly, J. S., Brain Res., 66, 289 (1974).
Iversen, L. L., and Bloom, F. E., Brain Res., 41, 131 (1972).
Braun, J. P., and Perham, R. N., Eur. J. Biochem., 39, 69 (1973).
Levi, G., and Raiteri, M., Brain Res., 57, 165 (1973).
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LEVI, G., RAITERI, M. Exchange of neurotransmitter amino acid at nerve endings can simulate high affinity uptake. Nature 250, 735–737 (1974). https://doi.org/10.1038/250735a0
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