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Arginase affects lactogenesis through its influence on the biosynthesis of spermidine

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Abstract

THE activity of arginase in mammary gland increases markedly during lactation1–3. Since lactating mammary gland, unlike liver, lacks other enzymes of the urea cycle3, the function of arginase in this gland is somewhat restricted. Results of earlier studies3,4 have suggested that the enzyme is involved in proline formation, in concert with ornithine aminotransferase, for increased synthesis of milk protein.

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Authors and Affiliations

  1. National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    TAKAMI OKA & JOHN W. PERRY

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  1. TAKAMI OKA
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  2. JOHN W. PERRY
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OKA, T., PERRY, J. Arginase affects lactogenesis through its influence on the biosynthesis of spermidine. Nature 250, 660–661 (1974). https://doi.org/10.1038/250660a0

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