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Virus-like particles induced in guinea pig cells by 5-bromo-2′-deoxyuridine are morphologically similar to murine B-type virus

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Abstract

VIRUS-LIKE particles in tissues of leukaemic and normal guinea pigs have been demonstrated repeatedly1–5. Tumour cells contain intracisternal particles resembling mouse intracisternal A particles3, and extracellular virus-like particles are found in tissues of leukaemic guinea pigs. To the best of our knowledge, a convincing micrograph of a virus-like particle budding from the surface of a guinea pig tumour cell (in vivo) has never been published. In a separate study (J.E.D. and K.P., in preparation), it has been concluded that the guinea pig leukaemia virus1–3 results from the release of intracisternal A particles from dying tumour cells.

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Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    JOHN E. DAHLBERG, KALMAN PERK & ALBERT J. DALTON

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  1. JOHN E. DAHLBERG
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  2. KALMAN PERK
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  3. ALBERT J. DALTON
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DAHLBERG, J., PERK, K. & DALTON, A. Virus-like particles induced in guinea pig cells by 5-bromo-2′-deoxyuridine are morphologically similar to murine B-type virus. Nature 249, 828–830 (1974). https://doi.org/10.1038/249828a0

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  • DOI: https://doi.org/10.1038/249828a0

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