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Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity

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Abstract

IT has been shown in mice that specific immunological unresponsiveness to contact sensitisation with picryl chloride induced by pretreatment with picryl sulphonic acid is a positive phenomenon rather than an absence of specific immunocompetent cells1. In this system it was shown that transfer of lymph node cells from unresponsive to normal mice would limit the recipients' contact sensitivity response to picryl chloride and that these cells had characteristics suggesting that they were T as opposed to B cells2. We should like to report that a similar state of unresponsiveness to the dinitrophenyl group in guinea pigs can be broken by treatment with cyclophosphamide (CY) just before sensitisation and this is associated with the return of the ability of T cells to proliferate in the draining lymph node as part of the immune response.

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Authors and Affiliations

  1. Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd, Basel, CH-4002, Switzerland

    L. POLAK

  2. Department of Pathology, Royal College of Surgeons of England, Lincoln's Inn Fields, London, WC2A 3PN, UK

    J. L. TURK

Authors
  1. L. POLAK
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  2. J. L. TURK
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POLAK, L., TURK, J. Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity. Nature 249, 654–656 (1974). https://doi.org/10.1038/249654a0

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  • DOI: https://doi.org/10.1038/249654a0

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