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Gangliosides as membrane receptors for tetanus toxin, cholera toxin and serotonin

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Abstract

Tetanus toxin is bound by a sialidase-labile disialosyl ganglioside, serotonin by another, and cholera toxin by a sialidase-stable monosialosyl ganglioside. There is good evidence that the monosialosyl ganglioside may be the receptor for cholera toxin in cell membranes; what of the disialosyl ganglioside and tetanus toxin?

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Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, UK

    W. E. van Heyningen

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  1. W. E. van Heyningen
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van Heyningen, W. Gangliosides as membrane receptors for tetanus toxin, cholera toxin and serotonin. Nature 249, 415–417 (1974). https://doi.org/10.1038/249415a0

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