Abstract
RECENT experiments1–3 indicate that cooperation between thymus derived lymphocytes (T cells) and antibody-forming cell precursors (B cells) is restricted by the H-2 gene complex. Helper activity in vivo operates only when T cells and B cells share at least one set of H-2 antigenic specificities. Evidence is presented here that the interaction of cytotoxic T cells with other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly restricted.
Similar content being viewed by others
References
Kindred, B., and Shreffler, D. C., J. immun., 109, 940 (1972).
Katz, D. H., Hamaoka, T., and Benacerraf, B., J. exp. Med., 137, 1405 (1973).
Katz, D. H., Hamaoka, T., Dorf, M. E., and Benacerraf, B., Proc. natn. Acad. Sci., U.S.A., 70, 2624 (1973).
Abelson, H. T., Smith, G. H., Hoffman, H. A., and Rowe, W. P., J. natn. Cancer Inst., 42, 497 (1969).
Kajima, M., and Majde, J., Naturwissenschaften, 57, 93 (1970).
Zinkernagel, R. M., and Doherty, P. C., J. exp. Med., 138, 1266 (1973).
Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., J. Immun. (in the press).
Doherty, P. C., and Zinkernagel, R. M., Transpln. Rev., 18 (in the press).
Marker, O., and Volkert, M., J. exp. Med., 137, 1511 (1973).
Blanden, R. V., Mackaness, G. B., and Collins, F. M., J. exp. Med., 124, 585 (1966).
Mims, C. A., and Subrahmanyan, T. P., J. Path. Bact., 91, 403 (1966).
Cerottini, J.-C., Nordin, A. A., and Brunner, K. T., Nature, 228, 1308 (1970).
Cerottini, J.-C., and Brunner, K. T., Adv. Immun. (in the press).
Cole, G. A., Prendergast, R. A., and Henney, C. S., Fedn. Proc., 32, 964 (1973).
Hecht, T. T., and Summers, D. F., J. Virol., 10, 578 (1972).
Lengerova, A., Adv. Cancer Res., 16, 235 (1972).
Perlmann, P., Perlmann, H., and Wigzell, H., Transpln. Rev., 13, 91 (1972).
MacLennan, I. C. M., Transpln. Rev., 13, 67 (1972).
Steele, R. W., Hensen, S. A., Vincent, M. M., Fuccillo, D. A., and Bellanti, J. A., J. Immun., 110, 1502 (1973).
Hotchin, J., Monogr. Virol., 3, 1 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ZINKERNAGEL, R., DOHERTY, P. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248, 701–702 (1974). https://doi.org/10.1038/248701a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/248701a0
- Springer Nature Limited
This article is cited by
-
A guide to thymic selection of T cells
Nature Reviews Immunology (2024)
-
Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?
International Journal of Hematology (2002)
-
Cancer gene and immunotherapy: recent developments
Medical Oncology (1999)
-
IFN-induced modulation of histocompatibility antigens on human cells
CANCER AND METASTASIS REVIEW (1988)
-
Non-H-2 and H-2-Linked immune response genes control the cytotoxic T-cell response to H-Y
Immunogenetics (1982)