Skip to main content
SpringerLink
Log in

Effects of β adrenergic blockade on plasma catecholamines in exercise

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IT is well established that physical exercise causes an increase in sympathetic activity, as shown by rises in the levels of plasma and urine catecholamines1. This increase in endogenous adrenergic activity can be used to study the effects of sympathetic stimulation. Such studies usually compare a control situation with one in which either α or β adrenergic receptor activity is blocked pharmacologically, thereby allowing study of both the blocked and unblocked receptors. Beta blocking drugs have been used in this way to study changes in carbohydrate metabolism2, free fatty acid metabolism3, and blood coagulation and fibrinolysis4 induced by exercise.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vendsalu, A., Acta physiol. scand., (suppl) 173, 8–114 (1960).

    Google Scholar 

  2. Brezinska, Z., and Nazar, K., Archs int. Physiol, 78, 883–892 (1970).

    Google Scholar 

  3. Muir, G. G., Chamberlain, D. A., and Tunstall, D., Lancet, ii, 930–932 (1964).

    Article  Google Scholar 

  4. Cohen, R. J., Epstein, S. E., Cohen, L. S., and Dennis, L. H., Lancet, i, 1264–1266 (1968).

    Article  Google Scholar 

  5. Halmagyi, D. F. J., Kennedy, M., and Varga, D., Europ. surg. Res., 3, 370–388 (1971).

    Google Scholar 

  6. McCullough, H., J. clin. Path., 21, 759–763 (1968).

    Article  CAS  Google Scholar 

  7. Von Euler, U. S., and Hellner, S., Acta physiol. scand., 26, 183–191 (1952).

    Article  CAS  Google Scholar 

  8. Von Euler, U. S., Clin. Pharmacol. Therap., 5, 398–404 (1964).

    Article  CAS  Google Scholar 

  9. Carruthers, M., Taggart, P., Conway, N., Bates, D., and Somerville, W., Lancet, ii, 62–67 (1970).

    Article  Google Scholar 

  10. Cumming, G. R., and Carr, W., Can. J. Physiol., 44, 465 (1966).

    Article  CAS  Google Scholar 

  11. Epstein, S. E., Robinson, B. F., Kahler, R. L., and Braunwald, E., J. clin. Invest., 44, 1745 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery,

    M. H. IRVING, B. J. BRITTON & W. G. WOOD

  2. Department of Clinical Pharmacology, St Bartholemew's Hospital, London

    C. PADGHAM

  3. Department of Chemical Pathology, St Mary's Hospital London,

    M. CARRUTHERS

Authors
  1. M. H. IRVING
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. J. BRITTON
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. G. WOOD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. PADGHAM
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. CARRUTHERS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

IRVING, M., BRITTON, B., WOOD, W. et al. Effects of β adrenergic blockade on plasma catecholamines in exercise. Nature 248, 531–533 (1974). https://doi.org/10.1038/248531a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/248531a0

  • Springer Nature Limited

This article is cited by

Search

Navigation