Abstract
THE rate of protein synthesis in eukaryotic cells can change rapidly as a result of translational control such as the inhibition of protein synthesis during mitosis1 or starvation2–4. Under these conditions a reversible inhibition of the initiation step of protein synthesis decreases the rate at which ribosomes become attached to messenger RNA. The continuing runoff of ribosomes from messenger during protein chain elongation and termination depletes the percentage of the total ribosomes which are in the form of polysomes and are synthesising protein.
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References
Fan, H., and Penman, S., J. molec. Biol., 50, 655–670 (1970).
Henshaw, E. C., Hirsch, C. A., Morton, B. E., and Hiatt, H. H., J. biol. Chem., 246, 436–446 (1971).
Lee, S. Y., Krsmanovic, V., and Brawerman, G., Biochemistry, 10, 895–900 (1971).
Van Venrooij, W. J. W., Henshaw, E. C., and Hirsch, C. A., Biochim. biophys. Acta, 259, 127–137 (1972).
Zeuthen, E., in Synchrony in Cell Division and Growth, (edit. by Zuethen, E.) 99–158 (Wiley, New York: 1964).
Padilla, G. M., and Cameron, I. L., J. cell comp. Physiol., 64, 303–307 (1964).
McCormick, W., and Penman, S., J. molec. Biol., 39, 315–333 (1969).
Schochetman, G., and Perry, R. P., J. molec. Biol., 63, 577–590 (1972).
Fuhr, J. E., Natta, C., Bank, A., and Marks, P. A., Biochim. biophys. Acta, 240, 70–73 (1971).
Pragnell, I. B., Marbaix, G., Arnstein, H. R. V., and Lebleu, B., FEBS Lett., 14, 289–292 (1971).
Whitson, G. L., Padilla, G. M., and Fisher, W. D., Expl. Cell Res., 42, 438–446 (1966).
Cameron, I. L., Griffin, E. E., and Rudick, M. J., Expl. Cell Res., 65, 265–272 (1971).
Noll, H., in Techniques in protein synthesis, vol. 2 (edit. by Campbell, P. N., and Sargent, J. R.), 101–179 (Academic Press, London, 1969).
Weeks, D. P., and Baxter, R., Biochemistry, 11, 3060–3064 (1972).
Baxter, R., Knell, V. C., Somerville, H. J., Swain, H. M., and Weeks, D. P., Nature new Biol., 243, 139–142 (1973).
Byfield, J. E., and Scherbaum, O. H., Proc. natn. Acad. Sci. U.S.A., 57, 602–606 (1967).
Byfield, J. E., and Lee, Y. C., Plant cell Physiol., 12, 461–646 (1971).
Rooney, D. W., and Eiler, J. J., Expl. Cell Res., 48, 649–652 (1967).
Fan, D. P., Higa, A., and Levinthal, C., J. molec. Biol., 8, 210–222 (1964).
Forchhammer, J., and Kjeldgaard, N. O., J. molec. Biol., 24, 459–470 (1967).
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KLEMPERER, H., ROSE, V. Decrease of polysomes in Tetrahymena after synchronisation shocks. Nature 248, 443–446 (1974). https://doi.org/10.1038/248443a0
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DOI: https://doi.org/10.1038/248443a0
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