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Insulin/proinsulin, a new crystalline complex

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Abstract

SINCE the first crystallisation of proinsulin in this laboratory1, we have tried to grow crystals appropriate for detailed X-ray crystal structure analysis. None of the pro-insulin crystal forms prepared proved ideal2, and we attempted to cocrystallise insulin and proinsulin. Such crystals, if both components were in ordered array, could provide a basis for the determination of the structure of proinsulin by the use of rigid-body vector search methods3,4 using the known stereochemistry of insulin5.

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Authors and Affiliations

  1. Department of Biochemistry, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, New York, New York, 10032

    BARBARA W. Low, W. WARDLE FULLERTON & LAWRENCE S. ROSEN

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  1. BARBARA W. Low
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  2. W. WARDLE FULLERTON
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  3. LAWRENCE S. ROSEN
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Low, B., FULLERTON, W. & ROSEN, L. Insulin/proinsulin, a new crystalline complex. Nature 248, 339–340 (1974). https://doi.org/10.1038/248339a0

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