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Activity of DNA templates during cell division and cell differentiation

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Abstract

THE rates of cellular RNA and DNA synthesis decline during the mitotic stages of cell division1 and during cell differentiation2. The molecular mechanisms mediating such a decline may include changes in the size of mononucleotide pools, changes in RNA and DNA polymerase activity, or changes in DNA template activity3, but previous studies have not distinguished among these possibilities. We have developed a high-resolution electron microscopic technique for directly analysing DNA template activity within living cells4, and now report its application to individual cells undergoing division and differentiation in human bone marrow.

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References

  1. Simmons, T., Heywood, P., and Hodge, L., J. cell Biol., 59, 150 (1973).

    Article  CAS  Google Scholar 

  2. Feinendegan, L. E., Bond, V. P., Cronkite, E. P., and Hughes, W. L., Ann. N.Y. Acad. Sci., 113, 727 (1964).

    Article  ADS  Google Scholar 

  3. Keshgegian, A. A., Meisner, L. F., and Frenster, J. H., in Proc. fourth Leukocyte Culture Conf., (edit. by Mclntyre, O. R.), 361 (Appleton-Century-Crofts, New York, 1971).

    Google Scholar 

  4. Frenster, J. H., Nature new Biol., 236, 175 (1972).

    Article  CAS  Google Scholar 

  5. Frenster, J. H., Cancer Res., 31, 1128 (1971).

    CAS  PubMed  Google Scholar 

  6. Frenster, J. H., Best, W. R., and Winzler, R. J., Proc. Soc. exp. Biol. Med., 98, 887 (1958).

    Article  CAS  Google Scholar 

  7. Robbins, E., and Gonatas, N. K., J. cell Biol., 21, 429 (1964).

    Article  CAS  Google Scholar 

  8. Anderson, D. R., J. Ultrastruc. Res. Suppl., 9, 5 (1966).

    Google Scholar 

  9. Bessis, M. C., and Breton-Gorius, J., Blood, 19, 635 (1962).

    Article  CAS  Google Scholar 

  10. Hollander, M., and Wolfe, D. A., Non-Parametric Statistical Methods (Wiley, New York, 1973).

    MATH  Google Scholar 

  11. Seligy, V. L., and Lurquin, P. F., Nature new Biol., 243, 20 (1973).

    CAS  PubMed  Google Scholar 

  12. Frenster, J. H., and Herstein, P. R., New Engl. J. Med., 228, 1224 (1973).

    Article  Google Scholar 

  13. Frenster, J. H., Nature, 208, 1093 (1965).

    Article  ADS  CAS  Google Scholar 

  14. Frenster, J. H., The Cell Nucleus (edit. by Busch, H.) 1, 565–580 (Academic Press, New York, 1974).

    Book  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Medical Oncology, Stanford University School of Medicine, Stanford, California, 94305

    SHIRLEY L. NAKATSU, MARILYN A. MASEK, SHARON LANDRUM & JOHN H. FRENSTER

Authors
  1. SHIRLEY L. NAKATSU
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  2. MARILYN A. MASEK
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  3. SHARON LANDRUM
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  4. JOHN H. FRENSTER
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NAKATSU, S., MASEK, M., LANDRUM, S. et al. Activity of DNA templates during cell division and cell differentiation. Nature 248, 334–335 (1974). https://doi.org/10.1038/248334a0

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  • DOI: https://doi.org/10.1038/248334a0

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