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Vitamin B12 antagonism by monocarboxylic acids and anilides of cyanocobalamin

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Abstract

VARIOUS test systems have been used to examine the anti-metabolite activity of vitamin B12 analogues1. In general, the tests have relied on the demonstration of growth inhibition or depression in either vitamin B12-requiring microorganisms or vitamin B12-deficient experimental animals. I have investigated the effect of the mixed isomeric monocarboxylic acids of cyanocobalamin and the anilides derived from these acids on the in vivo biochemical function of vitamin B12 in vitamin B12-depleted baboons.

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  1. Wellcome Trust Research Laboratories, PO Box 43640, Nairobi

    R. C. SIDDONS

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  1. R. C. SIDDONS
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SIDDONS, R. Vitamin B12 antagonism by monocarboxylic acids and anilides of cyanocobalamin. Nature 247, 308–309 (1974). https://doi.org/10.1038/247308a0

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  • DOI: https://doi.org/10.1038/247308a0

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