Abstract
MUCH work has been carried out aimed at elucidating the mode of action of thrombin on platelets1–5. These studies were based on the assumption that hydrolysis of a protein by thrombin constitutes the primary event culminating in aggregation of platelets. Results of recent studies suggest that the primary step in this process might be binding of thrombin to a receptor site, triggering viscous metamorphosis of the platelets6,7. The processes of binding and proteolysis need not be mutually exclusive, however, binding may be followed by proteolysis. Here I present direct evidence of thrombin binding by human platelets and discuss some of its implications.
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References
Ganguly, P., and Moore, R., Clin. chim. Acta, 17, 153 (1967).
Ganguly, P., Blood, 33, 590 (1969).
Nachman, R. L., Blood, 25, 703 (1965).
Kiesselbach, T. H., and Wagner, R. H., Am. J. Physiol., 211, 1472 (1966).
Baenziger, N. L., Brodie, G. N., and Majerus, P. W., J. biol. Chem., 247, 2723 (1972).
Majerus, P. W., and Brodie, G. N., J. biol. Chem., 247, 4523 (1972).
Detwiler, T. C., and Feinman, R. D., Biochemistry, 12, 282 (1973).
Ganguly, P., and Sonnichsen, W. J., J. clin. Pathol., 26, 635 (1973).
Lundblad, R. L., Biochemistry, 10, 2501 (1971).
McFarlane, A. S., J. clin. Invest., 42, 346 (1963).
Feagler, J. R., Tollefsen, D. M., and Majerus, P. W., J. clin. Invest., 52, 27 abstract (1973).
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GANGULY, P. Binding of thrombin to human platelets. Nature 247, 306–307 (1974). https://doi.org/10.1038/247306a0
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DOI: https://doi.org/10.1038/247306a0
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