Abstract
THE cytolysis of alloantigen-bearing target cells by thymus-derived (T) lymphocytes from appropriately immunized animals has particular relevance to allograft rejection (see ref. 1 for review). Although the mechanism of lysis remains imperfectly understood, recent studies suggest that it consists of multiple steps2–4 triggered by antigen-lymphocyte interaction5, which terminate in the secretion of a cytotoxic mediator protein into or onto the membrane of the target cell6,7.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Perlman, P., and Holm, G., Adv. Immunol., 11, 117 (1969).
Henney, C. S., and Bubbers, J. E., J. Immunol., 110, 63 (1973).
Berke, G., Sullivan, K. A., and Amos, B., J. Exp. Med., 136, 1594 (1972).
Henney, C. S., and Bubbers, J. E., J. Immunol. (in the press).
Rosenau, W., in Cell Bound Antibodies (edit. by Amos, B., and Koprowski, H.) (Wistar Institute Press, Philadelphia, 1963).
Bloom, B., Adv. Immunol., 13, 101 (1971).
Plaut, M., Lichtenstein, L. M., and Henney, C. S., J. Immunol., 110, 771 (1973).
Henney, C. S., and Lichtenstein, L. M., J. Immunol., 107, 610 (1971).
Henney, C. S., Bourne, H. R., and Lichtenstein, L. M., J. Immunol., 108, 1526 (1972).
Strom, T. B., Deisseroth, A., Morganroth, J., Carpenter, C. B., and Merrill, J. P., Proc. US Nat. Acad. Sci., 69, 2995 (1972).
Lichtenstein, L. M., Henney, C. S., Bourne, H. R., and Greenough, W. B., J. Clin. Invest., 52, 691 (1973).
Melmon, K. L., Bourne, H. R., Weinstein, Y., and Sela, M., Science, 177, 707 (1972).
Melmon, K. L., Weinstein, Y., Shearer, G. M., Bourne, H. R., and Sela, M., Israeli J. Med. Sci., 8, 641 (1972).
Shearer, G. M., Melmon, K. L., Weinstein, Y., and Sela, M., J. Exp. Med., 136, 1302 (1972).
Ash, A. S. F., and Schild, H. O., Brit. J. Pharmacol. Chemother., 27, 427 (1966).
Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., and Parsons, E. M., Nature, 236, 385 (1972).
Wyllie, J. H., Hesselbo, T., and Black, J. W., Lancet, ii, 1117 (1972).
Plaut, M., Lichtenstein, L. M., Gillespie, E., and Henney, C. S., J. Immunol. (in the press).
Brunner, K. T., Mauel, J., Cerottini, J. C., and Chapuis, B., J. Immunol., 14, 181 (1968).
Henney, C. S., J. Immunol., 107, 1558 (1971).
Brown, B. L., Albano, J. D. M., Ekins, R. P., Sgherzi, A. M., and Tampion, W., Biochem. J., 121, 561 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PLAUT, M., LICHTENSTEIN, L. & HENNEY, C. Increase in Histamine Receptors on Thymus-derived Effector Lymphocytes during the Primary Immune Response to Alloantigens. Nature 244, 284–287 (1973). https://doi.org/10.1038/244284a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/244284a0
- Springer Nature Limited
This article is cited by
-
Wide mutational spectrum of a gene involved in hormone action and insecticide resistance in Drosophila melanogaster
Molecular Genetics and Genomics (2006)
-
Classification and biological distribution of histamine receptor sub-types
Agents and Actions (1994)
-
An ultrastructural and developmental analysis of the corpus allatum of juvenile hormone deficient mutants ofDrosophila melanogaster
Roux's Archives of Developmental Biology (1993)
-
The effect of histamine on the development of adjuvant arthritis in the rat
Agents and Actions (1982)
-
Mast cell receptors controlling histamine release: Influences on the mode of action of drugs used in the treatment of adverse drug reactions
Klinische Wochenschrift (1982)