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α-Bungarotoxin used as a Probe for Acetylcholine Receptors of Cultured Neurones

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Abstract

THE snake venom protein α-bungarotoxin binds with specificity and high affinity to nicotinic acetylcholine receptors of striated muscle1–6, electric tissues7–9, and mammalian brain10. For these reasons, this toxin, as well as similar toxins from elapid snakes, has been used for labelling, purifying and assessing the physicochemical properties of cholinergic receptors.

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Authors and Affiliations

  1. Laboratory of Biochemical Genetics, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014

    LLOYD A. GREENE, ARTHUR J. SYTKOWSKI, ZVI VOGEL & MARSHALL W. NIRENBERG

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  1. LLOYD A. GREENE
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  2. ARTHUR J. SYTKOWSKI
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  3. ZVI VOGEL
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  4. MARSHALL W. NIRENBERG
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GREENE, L., SYTKOWSKI, A., VOGEL, Z. et al. α-Bungarotoxin used as a Probe for Acetylcholine Receptors of Cultured Neurones. Nature 243, 163–166 (1973). https://doi.org/10.1038/243163a0

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  • DOI: https://doi.org/10.1038/243163a0

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