Abstract
THERE is much evidence that metabolites of vitamin D are fundamentally involved in calcium absorption by the intestine. Cholecalciferol (vitamin D3) is hydroxylated at C25 in the liver1,2 and then at C1 in the kidney3–5. 1,25-dihydroxycholecalciferol is thought to be the active form, a hormone which promotes Ca transport by the intestine5–8. Ca translocation across the mucosal epithelial cell involves entry across the brush border and exit across the basal-lateral membrane. The site and manner of action of vitamin D metabolites has not been unequivocally established, but has been suggested to be at the basal-lateral membrane9, the brush border10,11, or both12,13. Kinetic studies in the normal rat led to the conclusion that entry across the brush border was rate-limiting for Ca translocation across the epithelium14. This would itself suggest that 1,25-dihydroxycholecalciferol regulated Ca absorption by acting at the brush border.
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PATRICK, G. The Regulation of Intestinal Calcium Transport by Vitamin D. Nature 243, 89–91 (1973). https://doi.org/10.1038/243089a0
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DOI: https://doi.org/10.1038/243089a0
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