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Effect of Hyperbaric Oxygen on Cultured Foetal Hearts

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Abstract

FOETAL mouse hearts and foetal hearts from other species have been shown to have remarkably consistent performance in organ culture. Wildenthal1,2 demonstrated that various substances added to an organ culture medium prolonged the survival of foetal hearts, and Hughes and Longmore3 showed that survival time and beating were related to the stage of development of the embryo, the younger hearts living and beating longer and better than the older hearts. Longmore and Hughes4 have shown that there is no difference in the performances of composite hearts made from parts of foetal hearts of different species at the same stage of maturity. It has been suggested by Wildenthal (personal communication) that the effect of substances on the heart may be different before and after the nerve end plates have developed.

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References

  1. Wildenthal, K., J. Appl. Physiol., 30, 153 (1971).

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  2. Wildenthal, K., Amer. J. Physiol., 221, 238 (1971).

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  3. Hughes, D. M., and Longmore, D. B., Nature, 235, 334 (1972).

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  4. Longmore, D. B., and Hughes, D. M., Nature, 238, 40 (1972).

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  5. New, D. A. T., in Advances in the Biosciences, Schering Symposium on Intrinsic and Extrinsic Factors in Early Mammalian Development (edit. by Raspe, G.) (Pergamon, Oxford, 1970).

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Authors and Affiliations

  1. National Heart Hospital, Westmoreland Street, London, W1M 8BA

    J. NAGLER & D. B. LONGMORE

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  1. J. NAGLER
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  2. D. B. LONGMORE
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NAGLER, J., LONGMORE, D. Effect of Hyperbaric Oxygen on Cultured Foetal Hearts. Nature 242, 197–198 (1973). https://doi.org/10.1038/242197a0

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  • DOI: https://doi.org/10.1038/242197a0

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