Skip to main content
Log in

Function of Lipophilic Acids as Antimicrobial Food Additives

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Most antimicrobial food additives are lipophilic acids which prevent growth by inhibiting the transport of substrate molecules into cells. The inhibition of transport was also observed in membrane vesicles, even when they were derived from organisms for which growth and transport are not affected by the larger inhibitors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Jencks, W. P., and Regenstein, J., in Handbook of Biochemistry—Selected Data for Molecular Biology (edit. by Sober, H. A.), J150 (The Chemical Rubber Co., Cleveland, 1968).

    Google Scholar 

  2. Chichester, D. F., and Tanner, jun., F. W., in Handbook of Food Additives (edit. by Furia, T. E.), 137 (The Chemical Rubber Co., Cleveland, 1968).

    Google Scholar 

  3. Ingram, M., Ottaway, F. J. H., and Coppock, J. B. M., Chemistry and Industry, 1, 1154 (1956).

    Google Scholar 

  4. Fortnagel, P., and Freese, E., J. Bact., 95, 1431 (1968).

    CAS  PubMed  Google Scholar 

  5. Sheu, C. W., and Freese, E., J. Bact., 111, 516 (1972).

    CAS  PubMed  Google Scholar 

  6. Konings, W. N., and Freese, E., J. Biol. Chem., 247, 2408 (1972).

    CAS  PubMed  Google Scholar 

  7. O'Leary, D. K., and Kralovec, R. D., Cereal Chemistry, 18, 730 (1941).

    CAS  Google Scholar 

  8. Sheu, C. W., Konings, W. N., and Freese, E., J. Bact., 111, 525 (1972).

    CAS  PubMed  Google Scholar 

  9. Leggett, J. E., Plant Physiol., 36, 277 (1961).

    Article  CAS  Google Scholar 

  10. Borst-Pauwels, G. W. F. H., and Jager, S., Biochim. Biophys. Acta, 172, 399 (1969).

    Article  CAS  Google Scholar 

  11. Kaback, H. R., and Milner, L. S., Proc. US Nat. Acad. Sci., 66, 1008 (1970).

    Article  ADS  CAS  Google Scholar 

  12. Freese, E., in Chemical Mutagens—Principles and Methods for their Detection (edit. by Hollaender, A.), 1 (Plenum Press, New York, 1971).

    Google Scholar 

  13. Overath, P., Pauli, G., and Schairer, H. U., Europ. J. Biochem., 7, 559 (1969).

    Article  CAS  Google Scholar 

  14. Weeks, G., Shapiro, M., Burns, R. O., and Wakil, S. J., J. Bact., 97, 827 (1969).

    CAS  PubMed  Google Scholar 

  15. Freese, E., and Fortnagel, U., J. Bact., 99, 745 (1969).

    CAS  PubMed  Google Scholar 

  16. Freese, E., Fortnagel, P., Schmitt, R., Klofat, W., Chappelle, E., and Picciolo, G., in Spores (edit. by Campbell, L. L.), 4, 82 (American Society for Microbiology, Bethesda, 1969).

    Google Scholar 

  17. Harold, F. M., Bact. Rev., 36, 172 (1972).

    CAS  PubMed  Google Scholar 

  18. Shapiro, R., Servis, R., and Welcher, M., J. Amer. Chem. Soc., 92, 422 (1970).

    Article  CAS  Google Scholar 

  19. Lijinsky, W., and Epstein, S., Nature, 225, 21 (1970).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

FREESE, E., SHEU, C. & GALLIERS, E. Function of Lipophilic Acids as Antimicrobial Food Additives. Nature 241, 321–325 (1973). https://doi.org/10.1038/241321a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/241321a0

  • Springer Nature Limited

This article is cited by

Navigation