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The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

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Figure 1: Exonuclease activity of wild-type WRN and the N333 fragment.
Figure 2: Helicase and exonuclease activities of wild-type and mutant WRN proteins.

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Acknowledgements

We thank S. Linn for valuable discussions and H. Asahara for technical advice. This work was supported by the National Institute on Ageing (grants AG11658 (J.C.); AG05776 (S.H.); AG14446 (J.O.)) and Department of Energy under contract DE-AC0376SF00098 to the University of California.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, 94720, California, USA

    Shurong Huang, Baomin Li & Judith Campisi

  2. Department of Pathology, University of Washington, Seattle, 98195, Washington, USA

    Matthew D. Gray & Junko Oshima

  3. Department of Radiation Biology, Lawrence Berkeley National Laboratory, Berkeley, 94720, California, USA

    I. Saira Mian

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  1. Shurong Huang
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  2. Baomin Li
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  6. Judith Campisi
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Correspondence to Judith Campisi.

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Huang, S., Li, B., Gray, M. et al. The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nat Genet 20, 114–116 (1998). https://doi.org/10.1038/2410

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